摘要
目的 分析膝关节置换术对晚期膝关节骨性关节炎(KOA)患者白细胞介素-1β(IL-1β)、超氧化物歧化酶(SOD)、转移生长因子-β1(TGF-β1)水平的影响。方法 选取2018年3月至2021年3月于大连市友谊医院进行KOA治疗的154例患者,根据治疗方法将其分为对照组(75例,常规治疗)和研究组(79例,全膝关节置换术)。观察两组治疗后3个月的治疗优良率;随访治疗前、治疗后3个月的疼痛视觉模拟评分法(VAS)评分、膝关节评分(HSS)和膝关节活动度;治疗前、治疗后3个月的血清中IL-1β、SOD、TGF-β1以及并发症。结果 研究组治疗总有效率为92.40%,高于对照组的49.33%,差异有统计学意义(P<0.05)。研究组VAS评分低于对照组,膝关节活动度以及HSS评分高于对照组,差异均有统计学意义(P<0.05)。研究组血清SOD、TGF-β1高于对照组,血清IL-1β低于对照组,差异均有统计学意义(P<0.05)。两组并发症发生率比较差异无统计学意义(P>0.05)。结论 全膝关节置换术能改善晚期KOA患者膝功能及活动度,促进骨损伤修复,减轻疼痛症状及炎症反应,具有较好的安全性。
Objective To analyze the effects of total knee arthroplasty on interleukin-1β(IL-1β),superoxide dismutase(SOD)and transforming growth factor-β1(TGF-β1)levels in patients with advanced knee osteoarthritis(KOA). Methods 154 patients who underwent KOA treatment in Dalian Friendship Hospital from March 2018 to March 2021 were selected,and they were divided into the control group(75 cases,conventional treatment)and the study group(79 cases,total knee arthroplasty)according to the treatment method.The excellent and good rates of the two groups were observed 3 months after treatment;the visual analogue scale(VAS)score,knee joint score(HSS)and knee joint range of motion were followed up before and 3months after treatment. Before and after treatment 3-month,the levels of serum IL-1β,SOD,TGF-β1 were compared. Results The total effective rate in the study group was 92.40%,which was higher than that of the control group(49.33%),and the difference was statistically significant(P<0.05). The VAS score in the study group was lower than that in the control group,and the range of motion of the knee joint and HSS score were higher than those in the control group,and the difference was statistically significant(P<0.05). The serum SOD and TGF-β1 in the study group were higher than those in the control group,and the serum IL-1β was lower than that in the control group,and the difference was statistically significant(P<0.05). There was no statistically significant difference in the incidence of complications between the two groups(P>0.05). Conclusion Total knee arthroplasty can improve knee function and range of motion in patients with advanced KOA,promote bone damage repair,relieve pain symptoms and inflammatory responses,and has good safety.
作者
刘立军
甘经岳
卢立军
LIU Lijun;GAN Jingyue;LU Lijun(Department of Traumatology,Dalian Friendship Hospital,Dalian,Liaoning,China,116000;Depart-ment of Joint and Sports Medicine,Dalian Friendship Hospital,Dalian,Liaoning,China,116000)
出处
《分子诊断与治疗杂志》
2023年第1期120-123,共4页
Journal of Molecular Diagnostics and Therapy
基金
大连市医学科学研究计划项目(1711028)。