摘要
临床药师参与1例晚期肾癌患者重度肝损伤的护肝治疗过程,分析患者的既往用药史,结合实验室检查,采用Naranjo’s评估表评估培唑帕尼片引起重度肝损伤的可能性。查阅文献资料并结合患者实验室检查特点,对培唑帕尼引起肝损伤的可能机制进行分析,建议临床及时停药并给予个体化护肝治疗,最终该患者肝损伤明显好转。临床药师结合药学知识与临床实践,为临床提供个体化给药建议,充分体现了临床药师的价值。本病例可为培唑帕尼所致重度肝损伤的诊断与治疗提供一定的借鉴。
Clinical pharmacists participated in the liver protection treatment process of a patient with advanced renal cell carcinoma with severe liver injury.By analyzing the patient’s previous medication history,combined with laboratory examination,the possibility of severe liver dysfunction caused by pezopanib tablets was evaluated by using Naranjo’s adverse drug reaction probability scale.Through consulting the literature and combined with the characteristics of patients’laboratory examination,the possible mechanism of liver injury caused by pezopanib tablets was analyzed.It was suggested that the clinical drug should be stopped in time and individualized liver protection treatment should be carried out.Finally,the patient’s liver injury was significantly improved.In this case,the clinical pharmacist combined pharmaceutical knowledge and clinical practice to provide effective pharmaceutical suggestions for the clinic,which fully reflects the value of the clinical pharmacist and provides a certain reference for the severe liver injury caused by pezopanib tablets in the future.
作者
王直滔
何玲芳
楼永海
Zhi-Tao WANG;Ling-Fang HE;Yong-Hai LOU(Taizhou Hospital of Zhejiang Province,Linhai 317000,Zhejiang Province,China;Linhai Hospital of Traditional Chinese Medicine,Linhai 317000,Zhejiang Province,China)
出处
《药物流行病学杂志》
CAS
2023年第1期116-120,共5页
Chinese Journal of Pharmacoepidemiology
关键词
培唑帕尼
肝损伤
药品不良反应
个体化给药
药学监护
Pezopanib
Liver injury
Adverse drug reactions
Individualized administration
Pharmaceutical care
