摘要
目的:分析艾滋病(acquired immune deficiency syndrome,AIDS)患者与普通呼吸科患者发生肺部感染的病原菌分布与耐药情况差异,为临床AIDS患者并发肺部感染的精准防治提供参考。方法:选取2016年1月—2020年1月无锡市第五人民医院传染科收治的98例并发肺部感染的AIDS患者作为AIDS组,选取同期医院呼吸科收治的98例发生肺部感染的普通患者作为非AIDS组,分析和比较2组患者痰标本中病原菌的分布与耐药情况差异。结果:98例AIDS组患者痰标本中检出的111株病原菌中革兰阴性菌70株(占63.06%)、革兰阳性菌13株(占11.71%)和真菌28株(占25.23%),而98例非AIDS组患者痰标本中检出的130株病原菌中革兰阴性菌87株(占66.92%)、革兰阳性菌9株(占6.92%)和真菌34株(占26.16%),2组患者痰标本中病原菌的分布大致相似(P>0.05);2组中主要病原菌的药敏结果显示,金黄色葡萄球菌对万古霉素、利奈唑胺、替加环素的耐药率均为0.00%,且对左氧氟沙星、四环素、庆大霉素、莫西沙星、复方磺胺甲噁唑的耐药率均较低(<30.00%),但非AIDS组中金黄色葡萄球菌还对苯唑西林、环丙沙星的耐药率较低(<30.00%);肺炎克雷伯菌对阿米卡星、头孢吡肟、亚胺培南、妥布霉素、哌拉西林-他唑巴坦钠、头孢替坦等的耐药率均较低(<20.00%)。结论:医院AIDS患者发生肺部感染的主要病原菌也是革兰阴性菌,且主要致病菌的耐药特点与普通肺部感染患者相似,但由于AIDS患者的免疫功能被破坏,感染导致的后果可能更为严重,故临床应加强对此类患者的监护与管理,以保证患者在感染后能得到及时有效的救治。
Objective: To analyze the distribution and drug resistance of pathogenic bacteria in pulmonary infection between AIDS(acquired immune deficiency syndrome) patients and ordinary patients in Pneumology Department, so as to provide reference for the precise prevention and treatment of AIDS patients with pulmonary infection. Methods: A total of 98 AIDS patients with pulmonary infection admitted to Department of Infectious Diseases of Wuxi No. 5 People’s Hospital from January 2016 to January 2020 were selected as AIDS group, and 98 ordinary patients with pulmonary infection admitted to Pneumology Department during the same period were selected as non-AIDS group, and the distribution and drug resistance of pathogenic bacteria in the sputum specimens from two groups of patients were analyzed and compared. Results: Among the 111 strains of pathogenic bacteria detected in the sputum specimens from 98 patients in the AIDS group, there were 70 strains of Gram-negative bacteria(63.06%), 13 strains of Gram-positive bacteria(11.71%) and 28 strains of fungi(25.23%). Among the 130 strains of pathogenic bacteria detected in the sputum specimens from 98 patients in the non-AIDS group, there were 87 strains of Gram-negative bacteria(66.92%), 9 strains of Grampositive bacteria(6.92%) and 34 strains of fungi(26.16%). The distribution of pathogenic bacteria in the sputum specimens of patients in the two groups was roughly similar(P>0.05);the drug susceptibility test results of main pathogenic bacteria in the two groups showed that the drug resistance rates of Staphylococcus aureus to vancomycin,linezolid and tigecycline were 0.00%, and its resistance rates to levofloxacin, tetracycline, gentamicin, moxifloxacin,and compound sulfamethoxazole were low(less than 30.00%);however, in the non-AIDS group, the resistance rates of Staphylococcus aureus to oxacillin and ciprofloxacin were low(less than 30.00%);the resistance rates of Klebsiella pneumoniae to amikacin, cefepime, imipenem, tobramycin, piperacillin-tazobactam sodium, cefotetan,
作者
潘虹
相旭博
王学贤
PAN Hong;XIANG Xu-bo;WANG Xue-xian(Wuxi No.5 People's Hospital,Wuxi Jiangsu 214011,China;Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China)
出处
《抗感染药学》
2022年第10期1410-1414,共5页
Anti-infection Pharmacy
关键词
肺部感染
艾滋病
病原菌分布
耐药特点
pulmonary infection
AIDS
distribution of pathogenic bacteria
drug resistance characteristics
