摘要
目前研究认为高血压是脑小血管病(cerebral small-vessel disease,CSVD)发生及进展的独立危险因素,而血压变异性作为衡量血压变化的重要指标,与脑小血管病的发病机制如脑组织低灌注、血管内皮细胞损害及炎症反应等密切相关,其可以更好地反应靶器官的受损情况,且不同类型的血压变异性指标对脑小血管病总负荷评分影响存在差异。但是,血压变异性与CSVD总负荷的关系尚不清楚。本文通过对血压变异性与脑小血管病总负荷评分之间的研究进展进行综述,发现血压变异性尤其是24 h收缩压变异性、夜间收缩压变异性等与脑小血管病总负荷之间密切相关,并且通过控制血压波动可能会减轻脑小血管病总负荷且改善脑小血管病患者认知功能障碍,为早期识别、干预及改善脑小血管病患者的预后提供更多思路。
Current research suggests that high blood pressure is an independent risk factor of occurrence and progression of cerebral small-vessel disease.Blood pressure variability,one of the important indicators to measure blood pressure change,is closely associated with the pathogenesis of CSVD such as cerebral hypoperfusion,vascular endothelial cell damage and inflammation.Therefore,it can better indicate target organ damage.In addition,different types of BPV indicators have different effects on the total brain MRI load score in patients with CSVD.However,the relationship between BPV and total imaging load of CSVD remains unclear.This article reviews the research progress on the relationship between BPV and brain MRI total load score in patients with cerebral small vessel disease to provide more clues for early identification,intervention and improvement of prognosis of patients with CSVD.
作者
龙晓月
毛文静
米唤金
孟琳
孙宝莹
刘斌
LONG Xiaoyue;MAO Wenjing;MI Huanjin;MENG Lin;SUN Baoying;LIU Bin(First Department of Neurology,the Affiliated Hospital of North China University of science and technology,Tangshan 063000,China)
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2023年第1期50-54,共5页
Chinese Journal of Nervous and Mental Diseases
基金
河北省医学科学研究课题计划(编号:20231276)
河北省医学重点科技研究计划项目(编号:20201226)。
关键词
脑小血管病
影像学标志物
总负荷
血压变异性
血压昼夜节律性
Cerebral small-vessel disease
Imaging markers
Brain total load score
Blood pressure variability
Circadian rhythm of blood pressure
