摘要
目的:应用血管回声跟踪技术评估和分析子痫前期(PE)孕妇的颈动脉僵硬度是否与正常妊娠孕妇存在差异,并分析病例组孕妇颈动脉僵硬度与PE严重程度和围产儿结局的相关性。方法:对30例PE孕妇及30例正常妊娠孕妇进行病例-对照研究。应用血管回声跟踪技术方法检测两组孕妇颈动脉僵硬度,得到以下检测指标:弹性压力(Ep)、硬化参数(β)、顺应性(AC)、单点脉搏波传导速度(PWVβ)和反射波增强指数(AI)。结果:PE组母体颈动脉Ep、β、PWVβ、AI明显高于对照组,AC明显低于对照组。PE组Ep、β、PWVβ和AI均与收缩压、舒张压和平均动脉压呈正相关。PE组孕妇颈动脉AI与新生儿体质量呈负相关,与1 min Apgar评分呈负相关。结论:PE孕妇颈动脉僵硬度较正常孕妇增加。PE孕妇颈动脉僵硬程度与血压呈正相关。PE孕妇颈动脉僵硬程度增高提示未来发生围产儿预后不良的可能性增大。
Objective: To determine whether the stiffness of the arterial walls of women with preeclampsia(PE) differed from that of healthy controls, and to evaluate its association with the severity of PE and perinatal outcomes in PE. Methods:We enrolled 30 women with PE and 30 normotensive pregnant women. Carotid artery stiffness was measured by Echo-tracking in both groups, and the following indexes were obtained: pressure-strain elastic modulus(Ep), stiffness parameter(β), arterial compliance(AC), pulse wave velocity(PWVβ) and augmentation index(AI). Results: In women with PE, Ep, β, PWVβ and AI were significantly higher than in the control group, while AC was significantly lower. Ep, β, PWVβ and AI were positively related with systolic blood pressure, diastolic blood pressure and mean arterial pressure in PE group. In women with PE, AI showed negative correlations with birth weight and 1 min Apgar score. Conclusions: The carotid arterial stiffness of patients with PE is increased. The carotid artery stiffness correlates positively with maternal blood pressure in PE group. The increased carotid stiffness in patients with PE suggests the possibility of poor perinatal outcomes.
作者
李婧宇
于一枝
LI Jing-yu;YU Yi-zhi(Department of Ultrasound,Shengjing Hospital,China Medical University,Shenyang 110004,China)
出处
《中国临床医学影像杂志》
CAS
CSCD
2023年第2期132-135,140,共5页
Journal of China Clinic Medical Imaging
基金
辽宁省科技厅科学技术计划项目(2013225086)。
