摘要
目的考察湿化经鼻高流量氧疗(HFNC)对肺癌术后患者感染、呼吸功能的影响。方法将70例行肺癌根治术的肺癌患者随机分为两组,对照组35例给予哌拉西林钠他唑巴坦钠常规抗感染治疗+常规氧疗,观察组35例给予哌拉西林钠他唑巴坦钠常规抗感染治疗+湿化经鼻高流量氧疗。分析并比较两组患者治疗7 d后的感染率,治疗前及治疗7 d后的血气分析指标、第1秒用力呼气容积占总肺活量比值(FEV1/FVC)、气道湿化及舒适度,并记录两组住院时间、机械通气率的差异。结果治疗7 d后,观察组患者术后感染率5.71%,明显低于对照组的22.86%(P<0.05);治疗前两组氧合指数(OI)、氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))、FEV1/FVC水平比较,差异均无统计学意义(P>0.05),治疗7 d后观察组OI[(332.67±37.38)%]、PaO_(2)[(83.12±9.06)mm Hg]、FEV1/FVC[(70.66±8.16)%]水平明显高于对照组[(300.25±32.52)%、(73.85±8.65)mmHg、(61.25±7.54)%],PaCO_(2)水平[(31.45±4.28)mmHg]明显低于对照组[(40.36±4.79)mmHg],差异具有统计学意义(P<0.01)。治疗7 d后,观察组气道湿化评分及舒适度评分为(1.27±0.65)分、(1.64±0.73)分,均明显低于对照组的(2.43±0.81)分、(2.29±0.85)分(P<0.01)。观察组住院时间(10.15±2.18)d,对照组住院时间(12.36±2.95)d,差异具有统计学意义(P<0.05)。两组机械通气率均为0,差异无统计学意义(P>0.05)。结论HFNC能够降低肺癌患者术后感染的发生率,改善肺癌术后患者呼吸功能,促进患者的恢复。
Objective To investigate the effects of high-flow nasal cannula oxygen therapy(HFNC)on the infection and respiratory function of patients after lung cancer surgery.Methods 70 lung cancer patients after surgical treatment were randomLy divided into two equal groups:The the control(35 cases)group were given piperacillin sodium tazobactam sodium conventional anti-infective therapy+conventional oxygen therapy,the observation group(35 cases)were given piperacillin sodium tazobactam sodium conventional anti-infective therapy+high-flow nasal cannula oxygen therapy.The infection rate after 7 days of treatment,the blood gas analysis indexes,the ratio of forced expiratory volume in 1 second to total vital capacity(FEV1/FVC),airway humidification and comfort before treatment and after 7 days of treatment were analyzed and compared between the two groups,and recorded the differences in hospital stay and mechanical ventilation rate between the two groups.Results After 7 days of treatment,the postoperative infection rate in the observation group was 5.71%,which was significantly lower than 22.86%in the control group(P<0.05).There were no significant difference in OI,PaO_(2),PaCO_(2)and FEV1/FVC levels between the two groups(P>0.05).After 7 days of treatment,OI[(332.67±37.38)%],PaO_(2)[(83.12±9.06)mmHg],FEV1/FVC[(70.66±8.16)%]in the observation group were significantly higher than those of the control group[(300.25±32.52)%,(73.85±8.65)mmHg,(61.25±7.54)%],PaCO_(2)[(31.45±4.28)mmHg]was significantly lower than that the control group[(40.36±4.79)mmHg](P<0.01).After 7 days of treatment,the airway humidification score and comfort score of the observation group were(1.27±0.65)points and(1.64±0.73)points,which were significantly lower than those of the control group(2.43±0.81)points and(2.29±0.85)points(P<0.01).The hospitalization time in the observation group was(10.15±2.18)d,and the hospitalization time in the control group was(12.36±2.95)d,and the difference was statistically significant(P<0.05).The mechanical ventila
作者
方天露
王亚丽
李玮娜
江宏
许亚丽
潘磊
FANG Tianlu;WANG Yali;LI Weina;JIANG Hong;XU Yali;PAN Lei(Department of Respiratory and Critical Care Medicine,Beijing Shijitan Hospital Affiliated to Capital Medical University,Beijing 100038,China)
出处
《中国急救复苏与灾害医学杂志》
2023年第2期203-206,共4页
China Journal of Emergency Resuscitation and Disaster Medicine
基金
首都医科大学附属北京世纪坛医院青年基金(编号:2018-q31)。
关键词
哌拉西林钠他唑巴坦钠
湿化经鼻高流量氧疗
肺癌
呼吸功能
感染
Piperacillin sodium and tazobactam sodium
Nasal high flow oxygen therapy(HFNC)
Lung cancer
Respiratory function
