摘要
突触蛋白-3α是2016年发现的一种可导致自身免疫性脑炎的新型抗体。抗突触蛋白-3α抗体相关脑炎患者一般伴有感染前驱症状或情绪改变,临床表现主要为癫痫发作、记忆障碍、意识模糊或昏迷、中枢性通气不足、异常行为和言语障碍等。笔者现围绕近年来该病的发病机制、诊断及鉴别诊断、治疗、预后等方面的国内外研究进展进行综述,以期拓展临床医生对该病的认识。
Neurexin-3α,discovered in 2016,is a new type of autoimmune encephalitis antibody.Anti-neurexin-3αantibody-associated encephalitis is generally associated with prodromal symptoms or mood changes,having main clinical manifestations as seizures,memory disorders,confusion or loss of consciousness,central ventilation insufficiency,abnormal behavior,and speech disorders.This paper reviews the relevant research progress at home and abroad about pathogenesis,diagnosis and differential diagnosis,treatment and prognosis of anti-neurexin-3αantibody-associated encephalitis,so as to expand the understanding of clinicians for this disease.
作者
陈家杰
朱红艳
刘玲春
符浩
刘达
杨顺宇
杨瑞晗
张明智
孟强
Chen Jiajie;Zhu Hongyan;Liu Lingchun;Fu Hao;Liu Da;Yang Shunyu;Yang Ruihan;Zhang Mingzhi;Meng Qiang(Department of Neurology,Affiliated Hospital of Kunming University of Science and Technology,First People's Hospital of Yunnan Province,Kunming 650032,China)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2023年第1期84-88,共5页
Chinese Journal of Neuromedicine
基金
云南省医学领军人才(L-2017013)
云南省万人计划-云岭名医(YNWR-MY-2018-018)
云南省基础研究专项-面上项目(202101AT070235)
云南省基础研究计划(昆医联合专项)(202101AY070001-245)。
