摘要
目的 探讨川崎病(Kawasaki disease, KD)并发冠状动脉瘤(coronary artery aneurysm, CAA)的危险因素,为早期预防和治疗CAA提供依据。方法 收集2019年1月—2021年12月在广州市妇女儿童医疗中心诊治的620例KD患儿资料进行回顾性分析,88例并发冠状动脉瘤(CAA组),532例未发生冠状动脉瘤(non-coronary artery aneurysm, NCAA组),其中NCAA组有41例诊断为冠状动脉扩张(coronary artery dilation, CAD)。对2组患儿的年龄、性别、红细胞沉降率(ESR)、白细胞计数(WBC)、红细胞计数(RBC)、血红蛋白(Hb)、血小板计数(PLT)、C-反应蛋白(CRP)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、白蛋白(ALB)、肌酸激酶同工酶(CKMB)、乳酸脱氢酶(LDH)、a-羟丁酸脱氢酶(HBDH)、N-端脑利钠肽前体(NT-proBNP)和尿酸(UA)等资料进行统计分析。对2组间比较差异有统计学意义的指标再行logistic回归分析,描述各指标的OR值及95%CI。结果 CAA组男性占比(78.41%)高于NCAA组(66.54%)(P<0.05);同时CAA组WBC、PLT、CRP和NT-proBNP高于NCAA组,RBC、Hb和ALB低于NCAA组(P<0.05)。logistic回归分析结果显示,ALB降低、PLT和NT-proBNP升高三者均为KD并发CAA的危险因素(P<0.05)。结论 ALB降低、PLT和NT-proBNP升高是KD患儿并发CAA的独立危险因素。
Objective This paper aims to study the risk factors of coronary artery aneurysm in children with Kawasaki disease(KD), so as to provide basis for the early prevention and treatment of coronary aneurysm. Methods Data of 620 children with KD treated in Guangzhou Women and Children’s Medical Center from January 2019 to December 2021 were retrospectively analyzed. 88 patients were complicated with coronary artery aneurysm. 532 patients didn’t occur coronary artery aneurysm, and coronary artery dilatation was diagnosed in 41 of them. Age, sex, erythrocyte sedimentation rate(ESR), white blood cell count(WBC), red blood cell count(RBC), hemoglobin(Hb), platelet count(PLT), C-reactive protein(CRP), alanine aminotransferase(ALT), aspartate aminotransferase(AST), albumin(ALB), creatine kinase isoenzyme(CKMB), lactate dehydrogenase(LDH), a-hydroxybutyrate dehydrogenase(HBDH), N-terminal pro-brain natriuretic peptide(NT-proBNP) and uric acid(UA) in the two groups were statistically analyzed. Logistic regression analysis was performed for the indicators with statistical significance in the comparison between the two groups, and the OR value and 95%CI of each indicator were described. Results The male proportion in CAA group(78.41%) was higher than that in NCAA group(66.54%)(P<0.05). WBC, PLT, CRP and NT-proBNP in CAA group were higher than those in NCAA group, while RBC, Hb and ALB were lower than those in NCAA group(P<0.05). Logistic regression analysis showed that ALB decreased, PLT increased and NT-proBNP increased, which are all risk factors for CAA in children with KD(P<0.05). Conclusion The decrease of ALB and the increase of PLT and NT-proBNP are the independent risk factors of CAA in children with KD.
作者
李梅爱
黄映红
杨丽媛
陈小红
邝婉仪
LI Mei-ai;HUANG Ying-hong;YANG Li-yuan;CHEN Xiao-hong;KUANG Wan-yi(Department of Laboratory,Guangzhou Women and Children's Medical Center,Guangdong 510120,China)
出处
《中国卫生检验杂志》
CAS
2023年第2期210-213,共4页
Chinese Journal of Health Laboratory Technology
关键词
川崎病
冠状动脉瘤
危险因素
儿童
Kawasaki disease
Coronary artery aneurysm
Risk factors
Children
