摘要
神经血管单元(NVU)的概念在2001年的一次卒中会议上形成。这一概念强调脑与其血管的密切关系,即脑细胞与脑血管之间在发育、结构和功能上相互依赖的共生关系。视网膜是脑神经组织的延伸,2007年一些研究者将NVU概念引入视网膜。视网膜的NVU包括神经元、胶质细胞、微血管内皮细胞和周细胞等。研究发现,NVU功能障碍在糖尿病视网膜病变(DR)中起关键作用,而现行有限的治疗集中在晚期并发症糖尿病性黄斑水肿及增生性DR,对视网膜NVU的深入研究将为早期或全程DR提供有效疗法。
·The concept of neurovascular unit(NVU),formalized in 2001 at a stroke conference,emphasizes the intimate relationship between the brain and its vessels,i.e.,symbiotic relationship between brain cells and cerebral blood vessels in the developmental,structural and functional interdependence.The retina is a piece of brain.Several researchers have introduced the concept of NVU to the retina since 2007.The NVU in the retina includes neurons,glial cells,microvascular endothelial cells and pericytes.Dysfunctional NVU plays a critical role in diabetic retinopathy(DR).The current limited treatments for DR focus on the late-stage complications,i.e.,diabetic macular edema and proliferative DR.While the further study on retinal NVU will develop efficacious therapeutic options for the early and all stages of DR.
作者
惠延年
Yan-Nian Hui(Eye Institute of PLA,Department of Ophthalmology,Xijing Hospital,Air Force Medical University,Xi an 710032,Shaanxi Province,China)
出处
《国际眼科杂志》
CAS
北大核心
2023年第3期353-355,共3页
International Eye Science
