摘要
目的观察基于因子分析的171例川崎病丙球敏感型患儿在丙种球蛋白干预下中医证候的演变规律。方法本研究为横断面分析研究。选择2019年7月-2020年12月广州市妇女儿童医疗中心心脏中心接受静脉注射丙种球蛋白(2 g/kg)治疗的川崎病住院患儿,根据治疗结果再选取丙球敏感型川崎病患儿171例,收集患儿四诊资料,观察卫分、气分、营分、阴分的代表证候,采用因子分析法进行证候演变规律分析。结果证候因子分析结果显示,治疗前171例丙球敏感型患儿KMO值为0.792,Bartlett球形检验具有显著性(P<0.01),提取出16个公因子,筛选出23个证候,主要涉及的证素有卫分证、气分证、营分证、阴分证、热凝血瘀证。治疗后1周KMO值为0.787,Bartlett球形检验具有显著性(P<0.01),提取出9个公因子,筛选出10个证候,主要涉及的证素有气虚证、阴虚证、血瘀证。结论川崎病丙球敏感型患儿治疗前中医证候主要为营分证、卫分证、气分证、阴分证和热凝血瘀证,治疗后中医证候主要为气虚证、阴虚证、血瘀证。
Objective To study the evolution of Traditional Chinese Medicine(TCM)syndromes of 171 cases of Kawasaki disease(KD)under the intervention of gamma globulin therapy based on factor analysis.Methods A cross‐sectional study.171 cases of KD children hospitalized in the Department of Cardiology of Guangzhou Women's and Children's Medical Center from July 2019 to December 2020 were collected.All patients were treated with intravenous gamma globulin(2 g/kg)for 1 week.According to the results of the treatment with C-ball,171 children with C-ball sensitive KD were selected to collect the four diagnostic data,and the representative syndromes of defensive level,qi level,yin level,and nutritive level were observed.Factor analysis was used to analyze the evolution of syndrome in 171 children with KD c-ball sensitivity.Results The result of factor analysis showed that the KMO statistics of 171 children with c-ball sensitivity before treatment was 0.792,and Bartley test was significant(P<0.01).16 common factors were extracted,and 23 syndromes were screened,mainly including defensive level disorder,qi level disorder,nutritive level disorder,yin level disorder,heat stagnation and blood stasis syndrome.One week after treatment,the statistic of KMO test was 0.787,and Bartley test was significant(P<0.01).9 common factors were extracted,and 10 syndromes were screened,mainly including qi deficiency syndrome,yin deficiency syndrome and blood stasis syndrome.Conclusion Before treatment,the TCM syndromes in KD C-cell sensitive children are mainly nutritive level disorder,defensive level disorder,qi level disorder yin level disorder,and heat stagnation and blood stasis syndrome;after treatment,the main TCM syndromes are mainly qi deficiency syndrome,yin deficiency syndrome and blood stasis syndrome.
作者
杨向娜
黄雨欣
刘佳铭
卢焯明
王燕飞
叶绮娜
李宁
徐方蔚
王莉
邓健
Yang Xiangna;Huang Yuxin;Liu Jiaming;Lu Zhuoming;Wang Yanfei;Ye Qina;Li Ning;Xu Fangwei;Wang Li;Deng Jian(TCM Pediatrics,Guangzhou Women and Children Medical Center,Guangzhou 510623,China;The Fifth Clinical Medical College of Guangzhou University of Chinese Medicine,Guangzhou 510405,China;The Second Clinical School of Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Heart Center,Guangzhou Women and Children Medical Center,Guangzhou 510623,China)
出处
《国际中医中药杂志》
2023年第2期141-147,共7页
International Journal of Traditional Chinese Medicine
基金
广东省中医药局基金项目(20212175、20201269)。
关键词
粘膜皮肤淋巴结综合征
川崎病
儿童
中医证候
中医证素
因子分析
丙种球蛋白
卫气营血
Mucocutaneous lymph node syndrome
Kawasaki disease
Child
TCM syndromes
TCM syndrome elements
Factor analysis
Gamma globulin
Wei Qi Ying Xue
