摘要
炎症性肠病(inflammatory bowel disease,IBD)是一种难治性肠道炎症性疾病,包括溃疡性结肠炎和克罗恩病,具有进行性且不可预测的病程特点。肠道炎症和免疫反应异常与IBD发病机制密切相关。自噬是细胞中重要的分解代谢过程,已被证明与包括IBD在内的多种炎症性疾病存在联系。本文从自噬功能障碍与IBD的关系出发,重点阐述了炎症小体抑制剂、肠道微生物群调节剂及其他信号调节剂等作用于肠上皮细胞和巨噬细胞的自噬调节剂在IBD中的研究进展。
Inflammatory bowel disease(IBD)is a group of chronic idiopathic colorectal inflammatory diseases with a progressive and unpredictable course,including ulcerative colitis(UC)and Crohn’s disease(CD).Abnormal intestinal inflammation and immune response contribute to the pathogenesis of IBD.Autophagy as an essential catabolic process in cells,has been demonstrated to have associations with a variety of inflammatory diseases including IBD.Here,we review the relationship between autophagy dysfunction and the process of IBD.The progress of several autophagy regulators for intestinal epithelial cells and macrophages is highlighted(inflammasome inhibitors,intestinal flora regulators,and other signal regulators)in the current studies on IBD.
作者
杨文盛
吴委
王静林
王广飞
李智平
YANG Wen-sheng;WU Wei;WANG Jing-lin;WANG Guang-fei;LI Zhi-ping(Department of Pharmacy,Children's Hospital of Fudan University,National Children's Medical Center,Shanghai 201102,China;Department of Pharmacy,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)
出处
《药学学报》
CAS
CSCD
北大核心
2023年第1期1-8,共8页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(81874325)
上海市科学技术委员会资助项目(18DZ1910604,19XD1400900,19DZ1910604)。
关键词
炎症性肠病
自噬
肠上皮细胞
巨噬细胞
肠道屏障
inflammatory bowel disease
autophagy
intestinal epithelial cell
macrophage
intestinal barrier
