摘要
分子伴侣介导的自噬(CMA)是一种特异性依赖于溶酶体的降解方式。通过靶向底物的KFERQ基序,CMA负责降解约30%的胞质蛋白,包括一系列与肿瘤发生、代谢、免疫和神经退行性疾病相关的蛋白。CMA的功能异常与恶性肿瘤、神经退行性疾病、代谢综合征及免疫功能紊乱等疾病有关。鉴于CMA功能障碍与肿瘤发生及神经退行性疾病的内在联系,CMA被认为是治疗恶性肿瘤和神经退行性疾病的重要靶标。
Chaperone-mediated autophagy(CMA)is a specific way of degradation that relies on lysosomes.By targeting the substrate’s KFERQ motif,the CMA is responsible for degrading approximately 30%of cytoplasmic proteins,including a range of proteins associated with tumorigenesis,metabolism,immunity,and neurodegenerative diseases.Abnormal CMA function is associated with malignancy,neurodegenerative diseases,metabolic syndromes,and immune disorders.Given the intrinsic link between CMA dysfunction and neoplastic and neurodegenerative diseases,CMA is considered an important target for the treatment of malignant tumors and neurodegenerative diseases.
作者
桂爱玲
曾虹雅
刘雯
左伋
杨玲
GUI Ailing;ZENG Hongya;LIU Wen;ZUO Ji;YANG Ling(Department of Cellular and Genetic Medicine,School of Basic Medical Sciences,Fudan University,Shanghai 200032,China)
出处
《中国优生与遗传杂志》
2023年第2期223-229,共7页
Chinese Journal of Birth Health & Heredity
基金
上海市大学生创新创业训练计划项目(S202210246238)
复旦大学卿枫学者项目(QF2123)。
关键词
分子伴侣介导的自噬
溶酶体相关膜蛋白2A
神经退行性疾病
视黄酸衍生物
chaperone-mediated autophagy
lysosomal-associated membrane protein 2A
neurodegenerative diseases
retinoic acid derivative
