摘要
目的 通过分析渝东南地区宫颈鳞状上皮内病变(SIL)患者高危型HPV型别分布,为该地区SIL与宫颈鳞癌(CSCC)患者的早期防治给予借鉴。方法 就医于重庆市黔江中心医院且由病理学(宫颈锥形切除或宫颈活检)确诊为CSCC的患者81例以及SIL患者300例。采用导流杂交技术检测宫颈SIL和CSCC患者的高危型HPV型别,然后统计分析患者感染的型别情况。结果 81例CSCC患者中,高危型HPV亚型按感染率从高到低排序为HPV16(53.08%)、HPV58(12.34%)、HPV18(9.88%)、HPV52(7.41%)、HPV33(3.70%)、HPV59(2.47%)、HPV11(1.23%)。SIL患者在高危型HPV感染率方面,亚型分布由高至低排序为:HPV16(32.67%)、HPV52(23.67%)、HPV58(23.67%)、HPV33(5.67%)、HPV39(4.33%)、HPV53(4.33%)、HPV18(3.67%)、HPV35(2.00%)。结论 感染HPV16/18的患者由宫颈SIL向CSCC转化的倾向较大,相反的感染HPV52/58的患者,由宫颈SIL向CSCC转化的倾向较小,同时患者是否为二重感染或多重感染并非其由宫颈鳞状上皮内病变向宫颈癌转化的影响因素。在该区域宫颈癌防治策略上须重点关注感染HPV16/18的患者,同时也要及时处理感染HPV52/58的患者。
Objective To provide evidence for early prevention and treatment of patients with cervical squamous intraepithelial lesions and cervical squamous cell carcinoma by studying the distribution of high-risk HPV types in patients with both disease in Southeast of Chongqing.Methods There were 81 patients with cervical squamous carcinoma and 300 patients with cervical squamous intraepithelial lesions who were admitted to the Qianjiang Central Hospital of Chongqing by pathology(cervical biopsy or cervical conization).Diversion hybridization technology was used to detect high-risk HPV types in patients with cervical squamous intraepithelial lesions, and statistically analyzes the types of infection.Results Among the 81 patients with cervical squamous cell carcinoma, the subtypes with higher infection rates of high-risk HPV were HPV16(53.08%),HPV58(12.34%),HPV18(9.88%),HPV52(7.41%),HPV33(3.70%),HPV59(2.47%),HPV11(1.23%).The distribution of high-risk HPV subtypes in patients with cervical squamous intraepithelial lesions is: HPV16(32.67%),HPV52(23.67%),HPV58(23.67%),HPV33(5.67%),HPV39(4.33%),HPV53(4.33%),HPV18(3.67%),HPV35(2.00%).Conclusion Patients infected with HPV16/18 have a greater tendency to transform from cervical squamous intraepithelial lesions to cervical squamous carcinoma.Conversely, patients infected with HPV52/58 have a lower tendency to transform from cervical squamous intraepithelial lesions to cervical squamous carcinoma.Whether the patient has double infection or multiple infection is not the influencing factor of the transformation from cervical squamous intraepithelial lesion to cervical cancer.In the prevention and treatment strategy of cervical cancer in this region, attention should be paid to patients infected with HPV16/18 and timely treatment should be given to patients infected with HPV52/58.
作者
胡森阳
唐雪
秦永
李小松
胡艳丽
刘小榕
邹海燕
杨淑娟
HU Sen-yang;TANG Xue;QIN Yong;LI Xiao-song;HU Yan-li;LIU Xiao-rong;ZOU Hai-yan;YANG Shu-ju(Department of Gynecology,Qianjiang Central Hospital of Chongqing,Congqing,409000,China)
出处
《中国妇幼保健》
CAS
2023年第3期404-407,共4页
Maternal and Child Health Care of China
基金
重庆市第三批区域医学重点学科建设项目(zdxk201802)
黔江区科技计划项目(黔科计2019019)。
关键词
宫颈鳞癌
鳞状上皮内病变
人乳头瘤病毒
高危亚型
Cervical squamous carcinoma
Cervical squamous intraepithelial lesions
HPV
High-risk types
