摘要
目的 探究丁苯酞、依达拉奉对老年脑小血管病(CSVD)患者血清炎性因子及血管内皮功能的影响。方法 选取老年CSVD患者82例为研究对象,随机分为丁苯酞注射液组(n=41)和依达拉奉注射液组(n=41)。依达拉奉注射液组采用依达拉奉注射液治疗,丁苯酞注射液组采用丁苯酞注射液治疗。治疗14 d后比较两组的治疗总有效率、治疗前后肿瘤坏死因子-α(TNF-α)、白介素6(IL-6)、白介素8(IL-8)等血清炎性因子,一氧化氮(NO)、血管内皮生长因子(VEGF)等血管内皮功能因子及美国国立研究院脑卒中量表(NIHSS)评分,并进行为期1年的随访,记录患者预后情况。结果 丁苯酞注射液组的治疗总有效率(90.24%)高于依达拉奉注射液组总有效率(75.61%)(P<0.05)。治疗后两组的TNF-α、IL-6、IL-8水平均降低,丁苯酞注射液组TNF-α、IL-6、IL-81水平均低于依达拉奉注射液组(P<0.05)。治疗后两组的NO水平升高、VEGF水平降低,且丁苯酞注射液组NO水平高于依达拉奉注射液组(P<0.05),VEGF水平低于依达拉奉注射液组(P<0.05)。治疗后两组的NIHSS评分较治疗前均降低,丁苯酞注射液组NIHSS评分低于依达拉奉注射液组(P<0.05)。随访1年后,丁苯酞注射液组患者预后情况优于依达拉奉注射液组(P<0.05)。结论 丁苯酞对老年CSVD患者疗效显著,可减轻患者炎症反应,改善患者血管内皮功能,疗效优于依达拉奉。
Objective To compare the effects of butylphthalide and edaravone on serum inflammatory factors and vascular endothelial function in elderly patients with cerebral small vessel disease(CSVD).Methods Eighty-two elderly CSVD patients were selected as the research objects, and were randomly divided into the butylphthalide injection group(n=41) and the edaravone injection group(n=41). The edaravone injection group were treated with edaravone injection, and the butylphthalide group was treated with butylphthalide injection. After 14 days of treatment, the total effective rate of the treatment, serum inflammatory factors [tumor necrosis factor-α(TNF-α), interleukin 6(IL-6), and interleukin 8(IL-8)], nitric oxide(NO), vascular endothelial growth factor(VEGF) and the National Institutes of Stroke Scale(NIHSS) scores were compared between the two groups before and after the treatment. The patients were followed up for 1 year and the prognosis was recorded.Results The total effective rate of the study group(90.24%) was significantly higher than that of the control group(75.61%)(P<0.05). After the treatment, the levels of TNF-α, IL-6, and IL-8 in the two groups were significantly reduced, and the levels of TNF-α, IL-6, and IL-81 in the butylphthalide injection group were lower than those in the edaravone injection group(P<0.05). After the treatment, NO levels were increased and VEGF levels were decreased in both groups, NO levels in the butylphthalide injection group was higher than that in the edaravone injection group and the VEGF levels in the butylphthalide injection group were signifi cantly lower than those in the edaravone injection group(P<0.05). After the treatment, the NIHSS scores of the two groups were significantly lower than those before the treatment, and the NIHSS score of the butylphthalide injection group was significantly lower than that of the edaravone injection group(P<0.05). After one year of follow-up, the prognosis of patients in the butylphthalide injection group was better than that in the edar
作者
胡彩彩
葛波波
孟颖
HU Caicai;GE Bobo;MENG Ying(Department of Neurology,The Second Affiliated Hospital of Bengbu Medical College,Bengbu 233080,Anhui,P.R.China;Department of Interventional Medicine,The Second Affiliated Hospital of Bengbu Medical College,Bengbu 233080,Anhui,P.R.China)
出处
《滨州医学院学报》
2023年第1期42-45,共4页
Journal of Binzhou Medical University
关键词
丁苯酞
依达拉奉
血管内皮功能
炎症因子
脑小血管
butylphthalide
edaravone
vascular endothelial function
inflammatory factor
cerebral small blood vessel
