摘要
【目的】观察岐黄针疗法治疗寒湿痹阻型膝骨关节炎的临床疗效及其对患者血清白细胞介素1β(IL-1β)和肿瘤坏死因子α(TNF-α)的影响。【方法】将60例寒湿痹阻型膝骨关节炎患者随机分为观察组和对照组,每组各30例,对照组给予常规针刺疗法治疗,观察组给予岐黄针疗法治疗,治疗1次为1个疗程,共治疗3个疗程。治疗3个疗程后,评价2组临床疗效,观察2组患者治疗前后西安大略和麦克马斯特大学骨关节炎指数(WOMAC)评分的变化情况,以及视觉模拟量表(VAS)评分的变化情况。比较2组患者治疗前后IL-1β和TNF-α水平的变化情况。【结果】(1)观察组总有效率为83.33%(25/30),对照组为80.00%(24/30),2组比较差异无统计学意义(P>0.05)。(2)治疗后,2组患者的WOMAC评分均明显改善(P<0.05)。观察组在改善WOMAC评分方面稍优于对照组,但差异无统计学意义(P>0.05)。(3)治疗后,2组患者的VAS评分均明显改善(P<0.05)。观察组在改善VAS评分方面稍优于对照组,但差异无统计学意义(P>0.05)。(4)治疗后,2组患者的TNF-α水平均明显改善,但差异无统计学意义(P>0.05)。观察组在改善TNF-α水平方面稍优于对照组,但差异无统计学意义(P>0.05)。(5)治疗后,2组患者的IL-1β水平均明显改善(P<0.05)。观察组在改善IL-1β水平方面稍优于对照组,但差异无统计学意义(P>0.05)。【结论】岐黄针疗法取穴少、耗材少、操作时间短。其治疗寒湿痹阻型膝骨关节炎,可缓解患者的疼痛症状,改善患者的关节功能,疗效显著,其作用机制可能与抑制外周血IL-1β水平相关。
Objective To observe the clinical efficacy of Qihuang acupuncture therapy on knee osteoarthritis(KOA)of cold-damp obstructing blockage syndrome type and its effect on patient’s serum interleukin 1β(IL-1β)and tumour necrosis factor α(TNF-α). Methods Sixty patients with cold-damp obstructing blockage type of KOA were randomly divided into the observation group and the control group, with 30 patients in each group. The control group was treated with conventional acupuncture therapy, while the observation group was treated with Qihuang acupuncture therapy. One treatment constituted a course of treatment,and the treatment lasted for a total of 3 courses of treatment. After three courses of treatment,the clinical efficacy of the two groups was evaluated,and the changes in the Western Ontario and McMaster Universities Arthritis Index(WOMAC)scores and the changes in the Visual Analogue Scale(VAS)scores were observed before and after treatment. The changes in IL-1β and TNF-α levels before and after treatment were compared between the two groups. Results (1)The total effective rate was 83.33%(25/30)in the observation group and 80.00%(24/30)in the control group. There was no statistically significant difference between the observation group and the control group(P>0.05).(2)After treatment,the WOMAC scores of patients in both groups were significantly improved(P<0.05). The observation group was slightly superior to the control group in improving the WOMAC score, but the difference was not statistically significant(P>0.05).(3)After treatment,the VAS scores of patients in both groups were significantly improved(P<0.05). The observation group was slightly superior to the control group in improving VAS scores,but the difference was not statistically significant(P>0.05).(4)After treatment,the TNF-α level of both groups was significantly improved,but the difference was not statistically significant(P>0.05). The observation group was slightly superior to the control group in improving the level of TNF-α, but the differenc
作者
凌翠敏
何挺
陈雨婷
林妙君
葛颖杰
LING Cui-Min;HE Ting;CHEN Yu-Ting;LIN Miao-Jun;GE Ying-Jie(Guangdong Second Hospital of Traditional Chinese Medicine,Guangzhou 510405 Guangdong,China;Guangzhou Liwan Orthopedic and Traumatology hospital,Guangzhou 510140 Guangdong,China;The Third Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510378 Guangdong,China)
出处
《广州中医药大学学报》
CAS
2023年第2期375-381,共7页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
广东省中医药局科研资助项目(编号:20200507172657)。
关键词
岐黄针疗法
寒湿痹阻型
膝骨关节炎
白细胞介素1Β
肿瘤坏死因子Α
临床观察
Qihuang acupuncture therapy
cold-damp obstructing blockage type
knee osteoarthritis(KOA)
interleukin-1β
tumour necrosis factor-α
clinical observation
