摘要
DearEditor,Methyl-CpG-binding protein 2(MeCP2)participates in regulating the expression of the CREB,TDP-43 and Dnmtl genes[1,2].Recent studies have shown that MeCP2 is essential for maintaining normal neural functions in the mammalian brain.Overexpression of MeCP2causes MECP2 duplication syndrome[3],a type of autism spectrum disorder that results in a core phenotype of social deficits in human patients[4],nonhuman primates[5],and rodents[6].
基金
This work was supported by the National Key R&D Program of China(2018YFC1705800)
Shanghai Municipal Science and Technology Major Project(2018SHZDZX01)
Shanghai Municipal Science and Technology Major Projects(2021SHZDZX0103 and 2017SHZDZX01)。
