摘要
肠道菌群是定植于人体胃肠道内的庞大微生物群,其稳态受损会导致肠上皮屏障功能障碍,引发肠道及全身疾病。研究揭示了甲状腺疾病患者与健康人肠道微生物群组成的差异以及肠道菌群对甲状腺激素代谢、对甲状腺功能的影响、与甲状腺疾病(桥本甲状腺炎,格雷夫斯病以及甲状腺癌)发生的可能关系。探究肠道菌群在甲状腺疾病中作用机制及治疗前景。
The gut microbiota is a large group of microbes found in the human gastrointestinal tract. Impaired gut microbiota homeostasis leads to intestinal epithelial barrier dysfunction that can lead to gut and systemic diseases. This study reveals the differences in composition of gut microbiota between patients with thyroid disease and healthy individuals, the effects of gut microbiota on thyroid hormone metabolism and thyroid function, as well as the possible relationship of gut microbiota with thyroid diseases(Hashimoto’s thyroiditis, Graves’ disease, and thyroid carcinoma). This study aims to explore the mechanism and treatment prospects of gut microbiota in thyroid diseases.
作者
王安洋
李超友
薛刚
吴靖芳
WANG Anyang;LI Chaoyou;XUE Gang;WU Jingfang(Hebei North University,Zhangjiakou 075000,Hebei,China;Department of Otorhinolaryngology&Head and Neck Surgery,The First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,Hebei,China)
出处
《山东大学耳鼻喉眼学报》
CAS
2023年第1期132-139,共8页
Journal of Otolaryngology and Ophthalmology of Shandong University
基金
河北省财政厅专科能力建设和带头人培养(361009)。
关键词
甲状腺-肠轴
肠道菌群
桥本甲状腺炎
格雷夫斯病
甲状腺癌
Thyroid-intestinal axis
Gut microbiota
Hashimoto’s thyroiditis
Graves’disease
Thyroid carcinoma
