摘要
椎间盘退行性变(IDD)是引起腰腿痛的主要疾病之一,严重影响患者的生活质量。近期许多研究发现白细胞介素6(IL-6)在退行性变的椎间盘组织和细胞中高表达,并与IDD的发生发展有着密切的联系。但关于IL-6在IDD中的信号通路和作用还不完全了解。因此,本文就IL-6在IDD中的信号通路及作用的研究进展进行综述,以期对临床工作及后续的科研工作提供帮助。
Intervertebral disc degeneration(IDD)is one of the main diseases causing low back pain,which seriously affects the quality of life of patients.Recent studies have discovered that interleukin-6(IL-6)is highly expressed in the tissues and cells of degenerative intervertebral disc and is closely related to the occurrence and development of IDD.However,the signaling pathway and role of IL-6 in IDD remain to be understood.Therefore,this article reviews the recent studies about the signaling pathway and role of IL-6 in IDD,aiming to facilitate the clinical work and subsequent research progress.
作者
陈金磊
王爽
王铭川
王昕
CHEN Jinlei;WANG Shuang;WANG Mingchuan;WANG Xin(The First Clinical Medical School of Lanzhou University,Lanzhou 730000,China;School of Public Health,Lanzhou University,Lanzhou 730000,China;Department of Orthopedics,905th Hospital,Naval Medical University,Shanghai 200003,China;Department of Spine,Changzheng Hospital,Naval Medical University,Shanghai 200003,China)
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2023年第1期134-142,共9页
Acta Academiae Medicinae Sinicae
基金
甘肃省自然科学基金(27JR7RA362、18JR3RA353)
中国博士后科学基金(2017M613342)
兰州市城关区科学与技术局基金(2017SHFZ0036)
兰州大学第一医院基金(ldyyyn2017-26)。
关键词
白细胞介素6
椎间盘退行性变
炎症反应
interleukin-6
intervertebral disc degeneration
inflammatory responses
