摘要
目的观察涤痰开窍中药复方治疗老年重症肺炎的临床疗效,并探讨其可能作用机制。方法67例患者以随机数字表法分为对照组与干预组。对照组给予西医常规治疗,干预组在西医常规治疗基础上服用涤痰开窍中药复方。比较治疗14 d后两组患者的生存状态,两组患者治疗前、治疗第3日、治疗第7日及第14日的临床肺损伤评分(CPIS评分)、急性生理和慢性健康评分(APACHEⅡ评分)、血清炎症指标水平,以及两组患者的机械通气时间和平均住院时间。结果治疗期间干预组有2例退出、对照组有4例退出,其余61例均完成相应治疗。干预组的病死率3.13%低于对照组的20.69%(P<0.05)。两组治疗3、7、14 d后APACHEⅡ评分、CPIS评分和血清炎症指标水平均优于治疗前(P<0.05或P<0.01),且干预组APACHEⅡ评分、CPIS评分和血清炎症指标水平在治疗后治疗第3日、第7日和第14日均优于对照组(均P<0.05或P<0.01)。治疗后干预组的机械通气和平均住院时间均低于对照组(均P<0.05)。两组治疗过程中均未出现明显不良反应。结论涤痰开窍中药复方可减轻炎症反应从而减轻肺损伤,降低老年重症肺炎患者病死率,可缩短机械通气和住院时间,延长生存时间,提高生存质量,改善预后。
Objective:To evaluate the clinical efficacy of traditional Chinese medicine compound for eliminating phlegm and inducing resuscitation in the treatment of elderly patients with severe pneumonia and explore its possible mechanism.Methods:A total of 67 elderly patients were divided into the control group and intervention group according to random number table method.The control group was given routine western medicine treatment according to the diagnosis and treatment standard,and the intervention group was given traditional Chinese medicine compound for eliminating phlegm and inducing resuscitation on the basis of routine western medicine treatment.The survival status of the two groups after 14 days of treatment was compared.The clinical pulmonary injury score(CPIS),acute physiology and chronic health evaluationⅡscore(APACHEⅡscore),serum inflammatory indicator level of the two groups before treatment,after 3,7 and 14 days of treatment were compared.The mechanical ventilation time and average hospitalization days were compared between the two groups.Results:During the treatment,2 cases in the intervention group withdrew,4 cases in the control group withdrew,and the remaining 61cases completed the treatment.The fatality rate of the intervention group was 3.13%,which was lower than20.69%of the control group(P<0.05).The APACHEⅡscore,CPIS score and serum inflammation index levels after 3,7 and 14 days of treatment were better than those before treatment(P<0.05 or P<0.01),and the APACHEII score,CPIS score and serum inflammation index level in the intervention group were better than those in the control group(all P<0.05 or P<0.01).The mechanical ventilation and mean length of hospital stay in the post-treatment intervention group were lower than those in the control group(all P<0.05).There were no significant adverse effects during treatment in either group.Conclusion:The traditional Chinese medicine compound of eliminating phlegm and inducing resuscitation can reduce the mortality of elderly patients with severe p
作者
赵远
岳宗相
杨松梅
唐虎
张洪
何俊安
Zhao Yuan;Yue Zongxiang;Yang Songmei;Tang Hu;Zhang Hong;He Junan(Meishan Hospital affitiated to Chendu University of Traditional Chinese Medicine,Sichuan,Meishan 620010,China)
出处
《中国中医急症》
2023年第2期301-304,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
四川省中医药管理局科学技术研究专项课题(2020LC0136)。
关键词
重症肺炎
老年
涤痰开窍
临床疗效
Severe pneumonia
Eliminating phlegm and inducing resuscitation
Clinical efficacy
