摘要
背景康复新液是一种可通利血脉、养阴生肌的中成药物制剂,可改善微循环,促进组织黏膜修复,对溃疡病症具有显著疗效.基于这一药效,本研究将其应用于胃溃疡的治疗,进一步分析其对胃溃疡的修复作用.目的探讨康复新液联合常规西药治疗胃溃疡的疗效观察及对血管内皮生长因子(vascular endothelial growth factor,VEGF)、细胞外调节蛋白激酶1/2(extracellular regulated protein kinase 1/2,ERK1/2)、水平的影响.方法前瞻性选取2021-01/2021-08我院48例胃溃疡患者作为研究对象,随机分为两组,各24例.对照组采取常规治疗+安慰剂;于此基础上,观察组予以康复新液治疗,疗程8 wk.观察两组临床效果、治疗前后黏膜微血管形态、血清指标[ERK1/2、VEGF、前列腺素E2(prostaglandin E2,PGE_(2))]、免疫应答T淋巴细胞亚群CD3+、CD4+、CD4+/CD8+水平、再生黏膜组织学成熟度及胃液pH值,记录不良反应发生率及复发率.结果观察组临床总有效率95.83%高于对照组66.67%(P<0.05);观察组规则微血管网比例高于对照组(P<0.05);观察组治疗后VEGF、ERK1/2、PGE_(2)水平高于对照组(P<0.05);观察组治疗后CD3+、CD4+、CD4+/CD8+均高于对照组(P<0.05);观察组胶原纤维沉积面积、Ⅰ/Ⅱ型胶原蛋白比值、羟脯氨酸含量及胃液pH值均高于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义,观察组3 mo复发率4.17%低于对照组33.33%(P<0.05).结论康复新液联合常规药物治疗胃溃疡,可显著提高临床疗效,促进溃疡愈合,降低复发风险,且不会明显增加药物不良反应.
BACKGROUND Kangfuxin solution can improve microcirculation and promote mucous membrane repair,and has a significant effect in ulcer disease.This study applied Kangfuxin solution to the treatment of gastric ulcer and analyzed its effect on the repair of gastric ulcer.AIM To investigate the efficacy of Kangfuxin solution combined with conventional Western medicine in the treatment of gastric ulcer complicated by chronic obstructive pulmonary disease and its effect on serum levels of vascular endothelial growth factor(VEGF)and extracellular regulated protein kinases 1/2(ERK1/2).METHODS Prospectively,48 patients with gastric ulcer treated at our hospital from January 2021 to August 2021 were selected as study subjects and randomly divided into either a control group or an observation group,with 24 cases in each group.Both groups received conventional treatments for gastric ulcer such as acid suppression,gastric mucosa protection,and antibiotics,and the observation group was additionally treated with Kangfuxin solution for 8 wk.The clinical effects,mucosal microvascular morphology,serum levels of ERK1/2 and VEGF,immune-responsive T lymphocyte subsets(CD3+,CD4+,CD4+/CD8+),histological maturation of the regenerated mucosa,gastric fluid p H,and the incidence of adverse effects and recurrence rate were recorded.RESULTS The overall clinical efficiency of the observation group was 95.83%,which was higher than that of the control group(66.67%;P<0.05).The proportion of regular microvascular network was higher in the observation group than in the control group(P<0.05).Serum levels of VEGF and ERK1/2 were higher in the observation group than in the control group after treatment(P<0.05).The percentages of CD3+T lymphocyte and CD4+T lymphocyte,and CD4+/CD8+ratio were higher in the observation group than in the control group(P<0.05).The area of collagen fiber deposition,typesⅠ/Ⅱcollagen ratio,hydroxyproline content,and gastric fluid p H were higher in the observation group than in the control group(P<0.05).There was no statist
作者
周文荣
胡明杰
王坚迪
Wen-Rong Zhou;Ming-Jie Hu;Jian-Di Wang(Department of Internal Medicine,General Hospital of the Third People’s Hospital of Cixi,Ningbo 315324,Zhejiang Province,China)
出处
《世界华人消化杂志》
CAS
2023年第1期28-34,共7页
World Chinese Journal of Digestology
关键词
康复新液
胃溃疡
免疫应答
Kangfuxin solution
Gastric ulcer
Immune response
