摘要
目的 分析吗啡鞘内输注镇痛治疗难治性癌痛患者的临床效果。方法 90例难治性癌痛患者,采用随机数字表法分为实验组和对照组,各45例。对照组患者采用静脉输注吗啡方式镇痛,实验组患者采用鞘内输注吗啡方式镇痛。比较两组患者的视觉模拟评分法(VAS)评分、不良反应发生情况、生活质量评分。结果 治疗后24 h、72 h、1周,实验组患者的VAS评分分别为(5.26±0.25)、(4.56±0.15)、(4.31±0.22)分,均显著低于对照组的(6.13±0.18)、(5.19±0.24)、(4.82±0.19)分,差异具有统计学意义(P<0.05)。实验组患者的不良反应发生率4.44%显著低于对照组的20.00%,差异具有统计学意义(P<0.05)。实验组患者的生理机能、情感职能、精神健康、社会功能评分分别为(37.52±6.46)、(36.69±7.12)、(45.38±7.25)、(43.82±6.33)分,均显著高于对照组的(21.23±6.97)、(14.25±5.38)、(24.26±6.58)、(21.73±5.36)分,差异具有统计学意义(P<0.05)。结论 在难治性癌痛患者的镇痛治疗中,相较于静脉输注吗啡,鞘内输注吗啡对于患者疼痛具有更加显著的改善效果,能够更好的提高患者的生活质量,减少不良反应,是更加有效的镇痛治疗手段。
Objective To analyze the analgesic effect of intrathecal morphine infusion in patients with refractory cancer pain. Methods A total of 90 patients with refractory cancer pain were divided into experimental group and control group by random numerical table, with 45 patients in each group. Patients in the control group were analgesized by intravenous morphine infusion, and patients in the experimental group were analgesized by intrathecal morphine infusion. The visual analogue scale(VAS) score, occurrence of adverse reactions, and the quality of life score in the two groups were compared. Results The VAS scores of patients in the experimental group were(5.26±0.25),(4.56±0.15), and(4.31±0.22) points at 24 h, 72 h, and 1 week after treatment, which were significantly lower than(6.13±0.18),(5.19±0.24), and(4.82±0.19) points in the control group, and the differences were statistically significant(P<0.05). The incidence of adverse reactions of the experimental group was 4.44%, which was significantly lower than 20.00% of the control group, and the difference was statistically significant(P<0.05). The physical function, emotional function, mental health, and social function scores of the patients in the experimental group were(37.52±6.46),(36.69±7.12),(45.38±7.25), and(43.82±6.33) points,which were significantly higher than(21.23±6.97),(14.25±5.38),(24.26±6.58), and(21.73±5.36) points in the control group, and the differences were statistically significant(P<0.05). Conclusion In the analgesic treatment of patients with refractory cancer pain, intrathecal morphine infusion has a more significant effect than intravenous morphine infusion, which can better improve the quality of life and reduce the adverse reactions of patients, and is a more effective analgesic treatment.
作者
欧丹贞
庄凤
OU Dan-zhen;ZHUANG Feng(Fuzhou First Hospital Affiliated to Fujian Medical University,Fuzhou 350001,China)
出处
《中国现代药物应用》
2023年第3期41-44,共4页
Chinese Journal of Modern Drug Application
关键词
难治性癌痛
吗啡
鞘内输注
疼痛程度
Refractory cancer pain
Morphine
Intrathecal infusion
Pain degree
