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肾炎康复片联合常规西药治疗慢性肾衰竭临床研究 被引量:1

Clinical Study on Shenyan Kangfu Tablets Combined with Conventional Western Medicine for Chronic Renal Failure
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摘要 目的:观察肾炎康复片联合常规西药治疗慢性肾衰竭的临床疗效及其对肾功能、血清炎性因子的影响。方法:选取慢性肾衰竭患者100例,按随机数字表法分为对照组和观察组各50例。对照组给予西药常规治疗,观察组在对照组基础上予以肾炎康复片治疗,共治疗8周。比较2组治疗前后肾功能、血清炎性因子水平,并评价2组临床疗效,观察不良反应以及转归情况。结果:观察组总有效率为92.00%,高于对照组78.00%(P<0.05)。与治疗前比较,治疗后2组血肌酐(SCr)、尿素氮(BUN)及24小时尿蛋白(24 hUp)水平降低,肾小球滤过率(GFR)升高(P<0.05);观察组SCr、BUN及24 h Up水平低于对照组,GFR高于对照组(P<0.05)。与治疗前比较,治疗后2组血清白细胞介素-6 (IL-6)、肿瘤坏死因子-α (TNF-α)水平降低(P<0.05),且观察组血清IL-6、TNF-α水平低于对照组(P<0.05)。治疗后12个月,观察组疾病减轻率为16.00%,高于对照组的4.00%(P<0.05)。观察组疾病进展率为8.00%,低于对照组24.00%(P<0.05)。结论:肾炎康复片联合西医常规治疗可提高慢性肾衰竭的临床疗效,延缓肾功能下降和疾病进程,并降低血清炎性因子水平,减轻机体炎症反应。 Objective:To observe the clinical effect of the therapy of Shenyan Kangfu Tablets combined with conventional western medicine on chronic renal failure and its influence on renal function and serum inflammatory factors. Methods:A total of 100 patients with chronic renal failure were randomly divided into the control group and the observation group,with 50 cases in each group. The control group was treated with conventional western medicine, and the observation group was additionally treated with Shenyan Kangfu Tablets based on the treatment of the control group,for a total of eight weeks. The levels of renal function and serum inflammatory factors were compared between the two groups before and after treatment,and the clinical effects,adverse reactions and outcomes were evaluated. Results:The total effective rate was 92.00% in the observation group,higher than that of 78.00% in the control group(P<0.05). After treatment,the levels of serum creatinine(SCr),urea nitrogen(BUN) and 24-hour urinary protein(24hUp) in the two groups were decreased when compared with those before treatment, and the glomerular filtration rate(GFR) was respectively increased(P<0.05);the levels of SCr,BUN and 24h Up in the observation group were lower than those in the control group,and the GFR level was higher(P<0.05).After treatment,the levels of serum interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) in the two groups were decreased when compared with those before treatment(P<0.05), and the levels of serum IL-6 and TNF-α in the observation group were lower than those in the control group(P<0.05). Twelve months after treatment,the remission rate of disease in the observation group was 16.00%,higher than that of 4.00% in the control group(P<0.05). The progression rate of disease in the observation group was8.00%, lower than that of 24.00% in the control group(P<0.05). Conclusion: The therapy of Shenyan Kangfu Tablets combined with conventional western medicine can improve the clinical effect of chronic renal failure, delay the decli
作者 陈茜芸 曾慧莲 周颖 柳磊 CHEN Qianyun;ZENG Huilian;ZHOU Ying;LIU Lei
出处 《新中医》 CAS 2023年第1期96-99,共4页 New Chinese Medicine
关键词 慢性肾衰竭 肾炎康复片 肾功能 炎症因子 疾病进程 Chronic renal failure Shenyan Kangfu Tablets Renal function Inflammatory factors Disease process
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