摘要
目的:观察加味四妙勇安汤治疗甲亢性心脏病气阴两虚兼痰瘀互结证的临床疗效。方法:采用随机数字表法将60例甲亢性心脏病患者分为对照组及研究组各30例。对照组采用常规西医治疗,研究组在对照组基础上加用加味四妙勇安汤治疗。比较2组治疗前后甲状腺功能、心功能、血脂指标及中医证候积分,并评估2组临床疗效及不良反应发生情况。结果:研究组治疗总有效率明显高于对照组(P<0.05)。治疗后,2组游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))水平均较治疗前明显下降(P<0.05),血清促甲状腺激素(TSH)水平较治疗前明显上升(P<0.05),且研究组治疗后甲状腺功能指标改善优于对照组(P<0.05)。治疗后,2组左室射血分数(LVEF)、二尖瓣前向血流E峰与A峰比值(E/A)较治疗前明显升高(P<0.05),左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)水平降低(P<0.05),且研究组治疗后心功能指标改善优于对照组(P<0.05)。治疗后,2组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平及中医证候积分较治疗前明显下降(P<0.05),高密度脂蛋白胆固醇(HDL-C)水平升高(P<0.05),且研究组治疗后上述指标改善优于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:加味四妙勇安汤治疗甲亢性心脏病疗效显著,能够有效改善患者甲状腺及心功能,降低血脂水平,安全性较高。
Objective:To observe the clinical effect of modified Simiao Yong’an Decoction for hyperthyroid heart disease with dual deficiency of qi and yin complicated with phlegm blended with blood stasis syndrome.Methods:A total of 60 cases of patients with hyperthyroid heart disease were divided into the control group and the study group according to the random number table method,with 30 cases in each group.The control group was treated with routine western medicine,and the study group was additionally treated with modified Simiao Yong’an Decoction based on the treatment of the control group.The indexes of thyroid function,heart function,and blood lipid and traditional Chinese medicine(TCM)syndrome scores before and after treatment were compared between the two groups;the clinical effects and the incidence of adverse reactions in the two groups were evaluated.Results:The total effective rate in the study group was significantly higher than that in the control group(P<0.05).After treatment,the levels of free triiodothyronine(FT_(3)) and thyroxine(FT_(4)) in the two groups were significantly decreased when compared with those before treatment(P<0.05),and the levels of thyroid-stimulating hormone(TSH) in serum were significantly increased(P<0.05);the improvement of thyroid function indexes in the study group was better than that in the control group(P<0.05).After treatment,the left ventricular ejection fraction(LVEF) and the ratio of peak E to peak A(E/A) of mitral valve forward blood flow in the two groups were significantly increased when compared with those before treatment(P<0.05),and the levels of left ventricular end-diastolic diameter(LVEDD) and left ventricular end-systolic diameter(LVESD) were decreased(P<0.05);the improvement of heart function indexes in the study group was better than that in the control group(P<0.05).After treatment,the levels of total cholesterol(TC),triglyceride(TG) and lowdensity lipoprotein(LDL-C),and TCM syndrome scores in the two groups were significantly decreased when compared with t
作者
陈思思
王雁秋
CHEN Sisi;WANG Yanqiu
出处
《新中医》
CAS
2023年第1期48-52,共5页
New Chinese Medicine
关键词
甲亢性心脏病
气阴两虚兼痰瘀互结证
四妙勇安汤
甲状腺功能
心功能
血脂
Hyperthyroid heart disease
Dual deficiency of qi and yin complicated with phlegm blended with blood stasis syndrome
Simiao Yong’an Decoction
Thyroid function
Heart function
Blood lipid
