摘要
目的观察针刺联合康复操治疗肌萎缩侧索硬化症(Amyotrophic lateral sclerosis,ALS)的临床疗效,以期为临床治疗肌萎缩侧索硬化症提供有效治法。方法选取2020年1月—2020年12月期间湖北省中医院推拿科/康复医学科收治的肌萎缩侧索硬化症患者60例,按随机数字表法分为对照组和治疗组,每组各30例。对照组予口服西药利鲁唑片50 mg,治疗组在对照组基础上予针刺联合康复操治疗。治疗14 d后,观察比较两组患者的临床疗效,治疗前后中医证候评分、肌萎缩侧索硬化症功能评分、Appel功能量表评分、血清中相关因子水平[白介素-1(Interleukin-1,IL-1)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、超氧化物歧化酶(Superoxide dismutase,SOD)]及不良反应情况。结果治疗后治疗组有效率83.33%优于对照组53.33%,差异有统计学意义(P<0.05)。治疗后两组患者ALS评分较治疗前升高,差异有统计学意义(P<0.05);且治疗组高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者Appel评分较治疗前降低,差异有统计学意义(P<0.05);且治疗组低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者中医证候评分较治疗前降低,差异有统计学意义(P<0.05);且治疗组低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者SOD、IL-1、TNF-α水平均较治疗前降低,差异有统计学意义(P<0.05);且治疗组SOD、IL-1、TNF-α水平低于对照组,差异有统计学意义(P<0.05)。结论针刺联合康复操治疗肌萎缩侧索硬化症确有良好疗效,值得临床应用推广与研究探讨。
Objective To observe the clinical effect of acupuncture combined with exercise on amyotrophic lateral sclerosis(ALS)and thus to provide effective therapy for clinical treatment of this disease.Methods A total of 60 ALS patients who were treated in Department of Neurology of Hubei Hospital of Traditional Chinese Medicine from January 2020 to December 2020 were randomized into treatment group(n=30)and control group(n=30).The control group was treated with Riluzole Tablets(50 mg,oral),while the treatment group was treated through acupuncture,exercise,and Riluzole Tablets(50 mg,oral).After 14 days of treatment,the clinical efficacy was observed and compared between the two groups,and the traditional Chinese medicine(TCM)syndrome score,ALS Functional Rating Scale(ALSFRS)score,Appel ALS Rating Scale(AALS)score,serum levels of interleukin-1(IL-1),tumor necrosis factor-α(TNF-α),superoxide dismutase(SOD)before and after treatment,and the occurrence of adverse reactions were compared between the two groups.Results The effective rate in the treatment group was 83.33%,higher than the 53.33%in the control group(P<0.05).After 14 days of treatment,the ALSFRS score was higher than that before treatment in both groups(P<0.05)and higher in the treatment group than in the control group(P<0.05).After treatment,the AALS score was lower than that before treatment in both groups(P<0.05)and lower in the treatment group than in the control group(P<0.05).After treatment,the TCM syndrome score was lower than that before treatment in both groups(P<0.05)and lower in the treatment group than in the control group(P<0.05).The serum levels of IL-1,TNF-α,and SOD in both groups were lower than that before treatment(P<0.05),and the levels were lower in the treatment group than in the control group(P<0.05).During the treatment,no obvious adverse reactions occurred in either group.Conclusion The combination of acupuncture and exercise is effective for ALS,which is worthy of clinical application and research.
作者
蔡芳芳
丁勇
范德兰
张艳
刘思敏
赵焰
CAI Fang-fang;DING Yong;FAN De-lan;ZHANG Yan;LIU Si-min;ZHAO Yan(Hubei Hospital of Traditional Chinese Medicine/Affiliated Hospital of Hubei University of Chinese Medicine/Hubei Institute of Traditional Chinese Medicine,Wuhan Hubei 430070)
出处
《世界中西医结合杂志》
2023年第1期137-141,共5页
World Journal of Integrated Traditional and Western Medicine
基金
湖北省科技厅湖北省技术创新项目(重大项目)(2017ACA192)。
关键词
肌萎缩侧索硬化症
针刺
康复操
Amyotrophic Lateral Sclerosis
Acupuncture
Exercise
