摘要
目的研究小剂量艾司氯胺酮用于预防瑞芬太尼持续输注后痛觉过敏的临床效果。方法将2021年1月-2022年1月在本院行全麻手术治疗的患者60例作为主要研究对象,所有患者均使用瑞芬太尼持续输注行麻醉诱导和麻醉维持。根据随机数字表法的原则将其分为两组,对照组(n=30)使用生理盐水预防痛觉过敏,观察组(n=30)使用小剂量艾司氯胺酮预防痛觉过敏,比较两组的苏醒时间、拔管时间、镇痛药物使用量、按压次数、疼痛程度以及不良反应发生率。结果观察组的苏醒时间(27.49±3.21)min、拔管时间(34.09±3.17)min与对照组相比,差异无统计学意义(P>0.05),观察组的镇痛药物使用量(54.13±3.12)mL小于对照组,按压次数(8.00±1.21)次少于对照组,差异有统计学意义(P<0.05);观察组患者术后30min、术后1h、术后2h、术后4h和术后24h的疼痛程度评分均小于对照组,差异有统计学意义(P<0.05);观察组的不良反应发生率与对照组相比,差异无统计学意义(P>0.05)。结论采用小剂量艾司氯胺酮预防瑞芬太尼持续输注后痛觉过敏的效果显著,可减少镇痛药物使用量,缓解患者的疼痛程度,故值得推广。
Objective To study the clinical effect of low dose esketamine in the prevention of hyperalgesia after continuous remifentanil infusion.Methods Sixty patients who underwent general anesthesia surgery in our hospital from January 2021 to January 2022 were selected as the main subjects of the study.All patients received continuous infusion of remifentanil for anesthesia induction and maintenance.According to the principle of random number table method will be divided into two groups,control group(n=30)use saline prevention hyperalgesia,observation group(n=30)using small doses of escitalopram ketamine prevention hyperalgesia,comparing two groups of waking time,extubation time,analgesic drug use,press the number,the degree of pain and the incidence of adverse reactions.Results There was no significant difference in the recovery time[(27.49±3.21)min]and extubation time[(34.09±3.17)min]between the observation group and the control group(P>0.05),and the dosage of analgesics in the observation group[(54.13±3.12)mL]was less than that in the control group.The number of pressing times[(8.00±1.21)]was less than that of the control group,and the difference was statistically significant(P<0.05).The pain score of observation group was lower than that of control group 30min,1h,2h,4h and 24h after surgery,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion The use of low-dose esketamine in the prevention of hyperalgesia after remifentanil continuous infusion has a significant effect,can reduce the use of analgesic drugs,relieve the pain degree of patients,so it is worth promoting.
作者
林俊铭
周淑梅
LIN Junming;ZHOU Shumei(Department of Anesthesiology,Panyu District Central Hospital,Guangzhou,Guangdong,511400)
出处
《智慧健康》
2022年第35期128-131,共4页
Smart Healthcare
