摘要
目的探讨血清Sestrin2在急性ST段抬高型心肌梗死(STEMI)中的表达及其与缺血再灌注损伤(IRI)的关系。方法选取STEMI患者124例作为STEMI组,并根据STEMI患者术后是否发生IRI将其分为IRI组(72例)和非IRI组(52例)。另选取健康志愿者50例作为对照组。检测所有研究对象的血清Sestrin2、丙二醛(MDA)、超氧化物歧化酶(SOD)及心肌肌钙蛋白(cTnI)水平。采用Pearson法分析STEMI患者血清Sestrin2与其他指标的相关性,多因素Logistic回归分析STEMI患者发生IRI的危险因素,受试者工作特征(ROC)曲线分析相关指标对STEMI患者发生IRI的预测价值。结果STEMI组血清Sestrin2、MDA水平高于对照组,血清SOD水平低于对照组(P<0.01);IRI组血清cTnI、Sestrin2、MDA水平高于非IRI组,血清SOD水平低于非IRI组(P<0.01);STEMI患者血清Sestrin2与MDA水平呈正相关,与血清SOD水平呈负相关(P<0.05)。多因素Logistic回归分析显示,血清Sestrin2、MDA水平升高是STEMI患者发生IRI的危险因素,而SOD水平升高则是保护因素(P<0.05)。经ROC分析显示,血清Sestrin2、MDA、SOD预测STEMI患者发生IRI风险的曲线下面积分别为0.759(95%CI:0.673~0.845)、0.654(95%CI:0.557~0.751)、0.671(95%CI:0.575~0.767),其中血清Sestrin2的预测价值最高。结论血清Sestrin2在STEMI患者中呈异常高表达,且其表达水平与患者是否发生IRI密切相关。
Objective To investigate the expression of serum Sestrin2 in acute ST-segment elevation myocardial infarction(STEMI)and its relationship with ischemia-reperfusion injury(IRI).Methods A total of 124 STEMI patients were selected as the STEMI group,and they were divided into the IRI group(72 cases)and the non-IRI group(52 cases)according to whether IRI occurred after surgery.Another 50 healthy volunteers were selected as the control group.Serum levels of Sestrin2,malondialdehyde(MDA)and superoxide dismutase(SOD)were detected in all subjects.Pearson’s method was used to analyze the correlation between serum Sestrin2 and other indicators in STEMI patients.Multivariate Logistic regression analysis was used to analyze the risk factors of IRI in STEMI patients.The receiver operating characteristic curve(ROC)was used to analyze the predictive value of relevant indicators for the occurrence of IRI in STEMI patients.Results The serum levels of Sestrin2 and MDA were significantly higher in the STEMI group than those in the control group,and the serum level of SOD was significantly lower than that in the control group(P<0.01).The serum levels of Sestrin2,MDA and cardiac troponin(cTnI)were significantly higher in the IRI group than those of the non-IRI group,and the serum SOD level was significantly lower than that of the non-IRI group(P<0.01).Serum Sestrin2 level was positively correlated with MDA level in STEMI patients,and it was negatively correlated with serum SOD level(P<0.05).Multivariate Logistic regression analysis showed that high serum levels of Sestrin2 and MDA were risk factors for IRI in STEMI patients,while high SOD level was protective factors(P<0.05).The ROC analysis showed that the areas under the curve of serum Sestrin2,MDA and SOD for predicting the risk of IRI in STEMI patients were 0.759(95%CI:0.673-0.845),0.654(95%CI:0.557-0.751)and0.671(95%CI:0.575-0.767),respectively,and serum Sestrin2 had the highest predictive value.Conclusion The expression of Sestrin2 is abnormally high in STEMI patients,and its
作者
滕丽峰
陈茜茜
叶丛
黄玉冰
TENG Lifeng;CHEN Xixi;YE Cong;HUANG Yubing(Department of Cardiology,Hainan Provincial People's Hospital,Haikou 570311,China;Department of Cardiology,Hainan Women and Children Medical Center)
出处
《天津医药》
CAS
北大核心
2023年第3期303-306,共4页
Tianjin Medical Journal
