摘要
目的观察黄芪地黄汤联合他克莫司治疗难治性肾病综合征(RNS)脾肾阳虚证的临床疗效。方法选取2018年1月至2020年2月许昌市中医院肾内科RNS脾肾阳虚证患者92例,采用随机数字表法分为对照组和治疗组,各46例。2组均采取激素常规治疗,在此基础上,对照组给予他克莫司口服治疗,治疗组给予黄芪地黄汤联合他克莫司口服治疗。连续治疗6个月后,比较2组的临床疗效以及治疗前后的肾功能指标[血尿素氮(BUN)、血肌酐(Scr)、24 h尿蛋白定量]水平。结果治疗组总有效率为89.13%(41/46),对照组为60.87%(28/46),2组比较差异有统计学意义(P<0.01);治疗后2组24 h尿蛋白定量、BUN、Scr水平明显降低,与同组治疗前比较差异均有统计学意义(P<0.05),且治疗组降低更明显,与对照组治疗后比较差异均有统计学意义(P<0.05)。结论黄芪地黄汤联合他克莫司治疗RNS脾肾阳虚证疗效显著,可有效改善患者肾功能,值得临床推广应用。
Objective To observe the clinical efficacy of Huangqi Dihuang Tang(黄芪地黄汤)combined with tacrolimus in the treatment of refractory nephrotic syndrome(RNS)with yang deficiency of spleen and kidney syndrome.Methods 92 cases of RNS with yang deficiency of spleen and kidney syndrome in the department of nephrology of Xuchang Hospital of Traditional Chinese Medicine from January 2018 to February 2020 were selected and divided into control group and treatment group according to random number table method,with 46 cases in each group.Both groups received conventional hormonal therapy.On this basis,the control group was given oral tacrolimus,and the treatment group was given Huangqi Dihuang Tang combined with tacrolimus.After 6 months of continuous treatment,the clinical efficacy and the levels of renal function indexes[blood urea nitrogen(BUN),serum creatinine(Scr)and 24 h urinary protein quantification J before and after treatment of the two groups were compared.Results The total effective rate was 89.13%(41/46)in the treatment group and 60.87%(28/46)in the control group,and the difference between the two groups was statistically significant(P<0.01).After treatment,24 h urinary protein quantification,BUN,Scr levels in 2 groups were significantly reduced,compared with the same group before treatment,the diferences were statistically significant(P<0.05),and reduction in the treatment group was more remarkable,compared with the control group after treatment,the differences were statistically significant(P<0.05).Conclusion Huangqi Dihuang Tang combined with tacrolimus in the treatment of RNS with yang deficiency of spleen and kidney syndrome has a significant clinical efficacy.It can effectively improve patients'kidney function,which is worthy of clinical promotion and application.
作者
包瑞杰
BAO Ruijie(Department of Nephrology,Xuchang Hospital of Traditional Chinese Medicine,Xuchang,Henan,461000,China)
出处
《甘肃中医药大学学报》
2022年第6期49-52,共4页
Journal of Gansu University of Chinese Medicine
关键词
难治性肾病综合征
脾肾阳虚证
黄芪地黄汤
他克莫司
肾功能
临床疗效
refractory nephrotic syndrome(RNS)
yang deficiency of spleen and kidney syndrome
Huangqi Dihuang Tang(黄芪地黄汤)
tacrolimus
kidney function
clinical efficacy
