摘要
目的了解云南省大理地区HIV/AIDS患者接受抗病毒治疗(ART)后病毒载量水平,评价ART疗效。方法对大理地区2021年1月1日至12月31日接受国家免费抗病毒治疗6个月以上的5727例HIV/AIDS患者免费检测病毒载量,对结果进行描述性流行病学分析。结果5727例HIV/AlDS患者中,病毒完全抑制患者4866例(84.97%,4866/5727);抗病毒治疗失败患者247例(4.31%,247/5727),其中112例患者对1种和(或)1种以上抗病毒药物耐药,耐药率为45.34%(112/247)。病毒学治疗失败与患者性别、年龄、婚姻、文化程度和治疗依从性相关(χ^(2)=75.43、4.21、149.84、136.83和523.17,P<0.001、=0.040、<0.001、<0.001和<0.001)。结论大理地区艾滋病患者群体实行ART后,病毒完全抑制的患者占比较高,效果显著。
Objective To investigate the viral load of HIV/AIDS patients after receiving antiretroviral therapy(ART)in Dali area of Yunnan,and to evaluate the efficacy of ART.Methods A total of 5727 HIV/AIDS patients who received national free ART for more than six months in Dali area were enrolled for free viral load test.The results were analyzed by descriptive epidemiological method.Results Of 5727 HIV/AIDS patients,4866 cases(84.97%,4866/5727)achieved complete viral suppression.There were 247 patients(4.31%,247/5727)with virological failure,among whom 112 were resistant to one and/or more antiviral drugs with the resistance rate of 45.34%(112/247).Gender,age,marriage,education and treatment adherence were factors that affected virological failure(χ^(2)=75.43,4.21,149.84,136.83 and 523.17,P<0.001,=0.040,<0.001,<0.001 and<0.001).Conclusions A large proportion of HIV/AIDS patients after receiving ART in Dali area achieve complete viral suppression and the efficacy of ART is remarkable.
作者
刘泽芬
张国丽
何秋阳
杨红樱
尤凤凤
尹世明
Liu Zefen;Zhang Guoli;He Qiuyang;Yang Hongying;You Fengfeng;Yin Shiming(Clinical Laboratory,Dali Bai Autonomous Prefecture People’s Hospital,Dali 671000,China;Department of Infectious Diseases,Dali Bai Autonomous Prefecture People’s Hospital,Dali 671000,China)
出处
《国际流行病学传染病学杂志》
CAS
2022年第6期382-385,共4页
International Journal of Epidemiology and Infectious Disease
关键词
HIV
抗病毒治疗
病毒载量
耐药
HIV
Antiretroviral therapy
Viral load
Drug resistance
