摘要
目的评价参芪扶正注射液联合西他赛+顺铂+5-氟尿嘧啶(Docetaxel+Cisplatin+5-Fluorouracil,DCF)化疗方案对胃癌患者造血功能和T细胞亚群的影响。方法选择2019年10月—2021年1月来医院治疗的胃癌患者85例为研究对象,依据随机数字表法将患者分为研究组和对照组,研究组42例,对照组43例。对照组采用DCF化疗方案,具体治疗方案:治疗第1天,静脉滴注多字紫杉醇75 mg/m^(2),第1~5天,静脉泵入5-氟尿嘧啶750 mg/m^(2),持续24 h;静脉滴注顺铂20 mg/m^(2)。1个治疗周期为28 d,共治疗4个周期。研究组在对照组治疗的基础上,静脉滴注参芪扶正注射液治疗,250 mL/次,14 d为1个治疗周期。研究组患者持续治疗4个周期。对比两组治疗前后食少纳呆、食后腹胀、体倦乏力和恶心呕吐等中医证候评分变化;对比两组治疗前后白细胞指数、血红蛋白和血小板含量变化;比较两组治疗前后淋巴细胞亚群(CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)),并计算CD_(4)^(+)/CD_(8)^(+),比较治疗总有效率。结果研究组治疗总有效率明显较高(P<0.05);两组治疗后食少纳呆、食后腹胀、体倦乏力和恶心呕吐等中医证候积分较治疗前降低,研究组治疗后食少纳呆、食后腹胀、体倦乏力和恶心呕吐等中医证候积分低于对照组(P<0.05);两组治疗后白细胞指数、血红蛋白和血小板含量较治疗前降低,研究组治疗后白细胞指数、血红蛋白和血小板含量低于对照组(P<0.05);两组治疗后免疫相关指标CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)和CD_(4)^(+)/CD_(8)^(+)较治疗前有了大幅度的改善,且研究组改善幅度优于参照组(P<0.05)。结论参芪扶正注射液结合DCF化疗方案可显著改善胃癌患者的临床症状,促进人体造血功能,提高机体免疫力,明显改善临床指标,提高治疗效果,在肿瘤化疗中具有显著的临床应用价值。
Objective To evaluate the effects of Shenqi Fuzheng Injection(参芪扶正注射液)combined with citaxel+cisplatin+5-fluorouracil(DCF)chemotherapy on hematopoietic function and T cell subsets in gastric cancer patients.Methods A total of 85 patients with gastric cancer who were treated in the hospital from October 2019 to January 2021 were selected as the study subjects.According to the random number table method,the patients were divided into study group and control group,with 42 cases in study group and 43 cases in control group.The control group received DCF chemotherapy regimen.The specific treatment regimen was as follows:On day 1 of treatment,multipaclitaxel was intravenously injected 75 mg/m^(2),and 5-fluorouracil 750 mg/m^(2) was intravenously pumped from day 1 to day 5 for 24 h.Cisplatin 20 mg/m^(2) was given intravenously.One treatment cycle was 28 days,and there were 4 treatment cycles.On the basis of the treatment in the control group,Shenqi Fuzheng Injection was intravenously dropped 250 mL/time for 14 d as a treatment cycle.Patients in the study group continued treatment for 4 cycles.The changes of traditional Chinese medicine symptom scores(such as asthenia,asthenia,abdominal distension,fatigue,nausea and vomiting)of the two groups were compared before and after treatment.The changes of white blood cells(WBC)index,hemoglobin and platelet content were compared between the two groups before and after treatment.The changes of immune-related indexes CD_(3)^(+),CD_(4)^(+),CD_(8)^(+) and CD_(4)^(+)/CD_(8)^(+) were compared between the two groups before and after treatment,and the total effective rate was compared.Results The results showed that the therapeutic effect of the study group was better(P<0.05).After treatment,the scores of traditional Chinese medicine symptoms such as asthenia,abdominal distension,fatigue,nausea and vomiting in the two groups were lower,and the scores in the study group were lower than those in the control group(P<0.05).After treatment,WBC index,hemoglobin and platelet conten
作者
苏瑞真
郑思超
黄运英
SU Ruizhen;ZHENG Sichao;HUANG Yunying(5th Affiliated Hospital of Guangzhou Medical University,Guangzhou 510000,Guangdong,China)
出处
《中华中医药学刊》
CAS
北大核心
2023年第1期226-229,共4页
Chinese Archives of Traditional Chinese Medicine
基金
广东省中医药管理局项目(20171176)。
关键词
参芪扶正注射液
DCF化疗方案
胃癌
造血功能
T细胞亚群
肿瘤生长
Shenqi Fuzheng Injection(参芪扶正注射液)
DCF chemotherapy regimen
gastric cancer
hematopoietic function
T cell subsets
tumor growth
