摘要
目的探讨玻璃酸钠(HA)联合盐酸氨基葡萄糖在半月板损伤的膝骨关节炎(KOA)患者中的疗效及患者半月板损伤恢复情况。方法选取2020年1月至2021年10月深圳市罗湖区人民医院风湿免疫科诊治的46例半月板损伤KOA患者作为研究对象,采用随机数字表法将其分为常规组和HA组,每组各23例。常规组患者采用盐酸氨基葡萄糖治疗,HA组患者采用HA联合盐酸氨基葡萄糖治疗。比较两组患者治疗前及治疗后12、24周的疼痛视觉模拟评分法(VAS)、Lysholm膝关节评分;比较两组患者治疗前及治疗后24周膝关节MRI半月板Stoller分级情况;比较两组患者的不良反应总发生率。结果HA组患者治疗后12、24周的疼痛VAS评分低于常规组,Lysholm膝关节评分高于常规组,差异有统计学意义(P<0.05);两组患者治疗后24周的疼痛VAS评分低于治疗后12周、治疗前,两组患者治疗后12周的疼痛VAS评分低于治疗前,差异有统计学意义(P<0.05);HA组患者治疗后24周的Lysholm膝关节评分高于治疗后12周、治疗前,两组患者治疗后12周的Lysholm膝关节评分高于治疗前,差异有统计学意义(P<0.05);两组患者治疗前及治疗后24周的膝关节MRI半月板Stoller分级情况比较,差异无统计学意义(P>0.05);两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论HA联合盐酸氨基葡萄糖治疗半月板损伤KOA患者,疼痛缓解更明显,长期改善关节功能更佳,不良反应轻微,但对半月板的修复无作用。
Objective To investigate the effect of Hyaluronic Acid(HA)combined with Glucosamine Hydrochloride in knee osteoarthritis(KOA)patients with meniscus injury and the recovery of meniscus injury.Methods A total of 46 KOA patients with meniscus injury in Department of Rheumatology and Immunology of Shenzhen Luohu District People's Hospital from January 2020 to October 2021 were selected as the study subjects.Random number table method was used to divide the patients into conventional group and HA group,with 23 cases in each group.The conventional group was treated with Glucosamine Hydrochloride,and the HA group was treated with HA combined with Glucosamine Hydrochloride.The visual analogue scale(VAS)and Lysholm knee score were compared between the two groups before treatment and 12,24 weeks after treatment.Stoller grading of knee MRI meniscus was compared between the two groups before and 24 weeks after treatment.The total incidence of adverse reactions was compared between the two groups.Results At 12 and 24 weeks after treatment,the pain VAS scores of HA group were lower than those of conventional group,and Lysholm knee scores of HA group were higher than those of conventional group,the differences were statistically significant(P<0.05).The pain VAS scores at 24 weeks after treatment in the two groups were lower than those at 12 weeks after treatment and before treatment,and the pain VAS scores at 12 weeks after treatment in the two groups were lower than those before treatment,the differences were statistically significant(P<0.05).Lysholm knee scores at 24 weeks after treatment in HA group were higher than those at 12 weeks after treatment and before treatment,and Lysholm knee scores at 12 weeks after treatment in two groups were higher than those before treatment,the differences were statistically significant(P<0.05).Stoller grading of knee MRI meniscus between the two groups before treatment and 24 weeks after treatment showed no significant difference(P>0.05).There was no significant difference in the total inci
作者
扶忠超
程小桂
姬静
史冉庚
FU Zhongchao;CHENG Xiaogui;JI Jing;SHI Rangeng(Department of Rheumatology and Immunology,Shenzhen Luohu District People's Hospital,Guangdong Province,Shenzhen518001,China;Department of Pharmacy,Shenzhen Luohu District People's Hospital,Guangdong Province,Shenzhen518001,China)
出处
《中国当代医药》
CAS
2023年第5期70-73,共4页
China Modern Medicine
基金
广东省深圳市罗湖区软科学研究计划项目(LX20191008)。
关键词
玻璃酸钠
关节腔注射
半月板损伤
膝骨关节炎
疼痛
Hyaluronic Acid
Intra-articular injection
Menisci injury
Knee osteoarthritis
Pain
