摘要
维生素D是一种影响肠道内稳态的免疫调节因子。最近有证据支持这种微量营养素在炎症性肠病(IBD)发展中的重要作用。本综述旨在概述维生素D可能的生物学作用机制(在免疫系统中的作用)及其对IBD的治疗意义。根据体外和动物研究表明,维生素D可改善上皮屏障的完整性,调节炎症反应,并影响免疫反应。最近的研究还表明,维生素D缺乏在IBD患者中非常普遍。越来越多的证据表明维生素D在IBD的病理生理学中起一定作用,维生素D通过调节先天免疫和适应性免疫在IBD中起到保护作用。因此,探讨维生素D作为治疗剂的在IBD中的潜在作用极为重要。
Vitamin D can regulate calcium and phosphorus metabolism and help achieve optimal bone homeostasis.In addition to its effects on bones,vitamin D is also related to a wide range of biological activities,such as the regulation of intestinal mucosal immunity and the integrity of intestinal barrier.Therefore,vitamin D deficiency is associated with the activity of immune-mediated diseases,including inflammatory bowel disease(IBD).The effect in the treatment of chronic inflammatory diseases(including IBD)has also been pointed out.
作者
聂思垚
姜威
Nie Siyao;Jiang Wei(School of Medical,Jiamusi University of Gastroenterology,The First Affiliated Hospital of Jiamusi University,Jiamusi 154000;Graduate Department of Jiamusi University,The First Affiliated Hospital of Jiamusi University,Jiamusi 154000,China)
出处
《广东化工》
CAS
2023年第2期59-61,共3页
Guangdong Chemical Industry
