摘要
糖尿病骨质疏松症(diabetic osteoporosis,DOP)是由糖尿病(diabetes mellitus,DM)诱发的慢性骨代谢疾病,其特征为骨量减少、骨脆性增加、强度降低以及易于发生骨折等。为更好地探索糖尿病骨质疏松发病机制,并为其治疗研究提供依据,建立出能够模拟人类糖尿病骨质疏松病理学的动物模型具有重要价值。通过链脲佐菌素(streptozotocin,STZ)诱导建立糖尿病骨质疏松动物模型的方式具有操作简单、用时短、成模率高、稳定性相对较高等优势,本文从动物选择、饲料喂养、链脲佐菌素的应用、造模方法、成模标准及检测指标等方面进行综述,希望能够为更加深入研究糖尿病骨质疏松致病机制提供基础和依据。
Diabetic osteoporosis(DOP)is a chronic bone metabolic disease induced by diabetes mellitus,which is characterized by a decreased bone mass,increased bone fragility,decreased strength,and fracture tendency.To better explore the pathogenesis of DOP and develop treatments,it is important to establish an animal model that mimics the pathology of human DOP.The method of establishing a DOP animal model induced by streptozotocin has the advantages of simple operation,short time,high molding rate and relatively high stability.This article reviews animal selection,feeding,streptozotocin application,modeling method,modeling criteria,and testing indexes to provide a basis for more in-depth research of DOP pathogenesis.
作者
孙立亚
刘北
奚悦
SUN Liya;LIU Bei;XI Yue(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;the Third Affiliated Hospital of Jinzhou Medical University,Jinzhou 121001)
出处
《中国实验动物学报》
CAS
CSCD
北大核心
2022年第7期1003-1012,共10页
Acta Laboratorium Animalis Scientia Sinica
