摘要
肺动脉高压(pulmonary hypertension,PH)是一种罕见且严重的进行性疾病,在无左心、肺实质或血栓栓塞性疾病的情况下,由远端肺小动脉肥厚性重构增加肺动脉压和肺血管阻力所致。低氧诱导因子1(hypoxia-inducible factor-1,HIF-1)调控大量与PH发生发展相关的基因,诱导肺血管生成、细胞增殖和迁移以及细胞能量代谢和利用等。HIF-1是低氧性PH发病机制的重要组成部分,在驱动肺血管和右心室重构的病理过程中发挥重要作用。本文就HIF-1在低氧性PH中的作用和调控及其在靶向治疗PH中的潜力进行系统阐述。
Pulmonary hypertension(PH)is a rare and severe progressive disease.It results from hypertrophic remodeling of distal pulmonary arterioles that increases pulmonary arterial pressure and pulmonary vascular resistance in the absence of left heart,pulmonary parenchymal,or thromboembolic disease.Hypoxia-inducible factor-1(HIF-1)regulates a large number of genes related to the occurrence and development of PH,and induces pulmonary angiogenesis,cell proliferation and migration,cellular energy metabolism and utilization.HIF-1 is an important component of the pathogenesis of hypoxic PH and plays an important role in driving the pathological process of pulmonary vascular and right ventricular remodeling.This article systematically elucidated the role and regulation of HIF-1 in hypoxic PH and its potential in targeted therapy of PH.
作者
沈畅
艾可龙
胡长平
SHEN Chang;AI Kelong;HU Changping(Department of Pharmacology,Xiangya School of Pharmaceutical Sciences,Central South University,Key Laboratory of Cardiovascular Research of Hunan Province,Changsha 410078,Hunan,China)
出处
《中国临床药理学与治疗学》
CAS
CSCD
2023年第1期114-120,共7页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
肺动脉高压
低氧诱导因子1
肺动脉内皮细胞
肺动脉平滑肌细胞
肺动脉成纤维细胞
pulmonary hypertension
hypoxia-inducible factor-1
pulmonary artery endothelial cells
pulmonary artery smooth muscle cells
pulmonary artery adventitial fibroblasts
