摘要
目的探讨计算机断层扫描(CT)联合血清甲胎蛋白、热休克蛋白90α(Hsp90α)、铁蛋白对肝细胞肝癌(HCC)的临床诊断价值。方法回顾性选择2019年8月至2021年12月在湖北省中西医结合医院确诊的HCC患者80例为HCC组,另选取同期良性肝病患者75例作为对照组。分析所有观察对象CT表现特征,化学放光法检测血清甲胎蛋白、铁蛋白水平,酶联免疫吸附试验检测血清Hsp90α水平,受试者工作特征(ROC)曲线分析CT、联合血清甲胎蛋白、Hsp90α、铁蛋白对肝癌的诊断价值,评价CT联合血清甲胎蛋白、Hsp90α、铁蛋白对HCC的诊断效能。结果CT检查结果显示,病理诊断为HCC的80例患者中,CT诊断出HCC患者62例,CT诊断HCC的敏感度为77.50%(62/80),特异度为81.33%(61/75),准确度为79.35%。HCC组患者血清甲胎蛋白、Hsp90α、铁蛋白水平均显著高于对照组,差异均有统计学意义(P<0.05)。血清甲胎蛋白、Hsp90α、铁蛋白联合诊断HCC为70例,CT+血清指标诊断HCC为75例;CT联合血清甲胎蛋白、Hsp90α、铁蛋白诊断HCC的敏感度为93.75%、特异度为78.67%,准确度为88.39%,其诊断效能显著高于CT、血清甲胎蛋白、Hsp90α、铁蛋白诊断,ROC曲线分析显示,联合诊断的曲线下面积显著高于单独诊断。结论CT联合血清甲胎蛋白、Hsp90α、铁蛋白对HCC的诊断有一定价值,有一定临床应用意义。
Objective To investigate the clinical value of computed tomography(CT)combined with serum alpha-fetoprotein,heat shock protein 90α(Hsp90α)and ferritin in the diagnosis of hepatocellular carcinoma(HCC).Methods Eighty HCC patients diagnosed in Hubei Integrated Hospital of Traditional Chinese and Western Medicine from August 2019 to December 2021 were regarded as HCC group,and another 75 patients with benign liver disease were regarded as the control group.The CT features of all the observed objects were analyzed,the levels of serum alpha-fetoprotein and ferritin were detected by chemiluminescence method.The serum level of Hsp90αwas detected by enzyme-linked immunosorbent assay.The diagnostic value of CT combined with serum alpha-fetoprotein,Hsp90αand ferritin for liver cancer was analyzed by receiver operating characteristic(ROC)curve,and the diagnostic efficacy of CT combined with serum alpha-fetoprotein,Hsp90αand FER for HCC was evaluated.Results CT examination results showed that among the 80 patients with pathological diagnosis of HCC,62 patients were diagnosed with HCC by CT,the sensitivity of CT in diagnosing HCC was 77.50%(62/80),the specificity was 81.33%(61/75),and the accuracy was 79.35%.The serum levels of alpha-fetoprotein,Hsp90αand ferritin in patients with HCC group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).The sensitivity of CT combined with serum alpha-fetoprotein,Hsp90αand ferritin in the diagnosis of HCC was 93.75%,the specificity was 78.67%,and the accuracy was 88.39%,and its diagnostic efficiency was significantly higher than that of CT,serum alpha-fetoprotein,Hsp90α,and ferritin.The area under the curve for diagnosis was significantly higher than that for diagnosis alone.Conclusion CT combined with serum alpha-fetoprotein,Hsp90αand ferritin has certain value in the diagnosis of HCC,and has certain clinical application significance.
作者
彭万宏
门秀丽
宋浩
PENG Wan-hong;MEN Xiu-li;SONG Hao(Department of Radiology,Hubei Hospital of Integrated Traditional Chinese and Western Medicine/Xinhua Hospital Affiliated to Hubei University of Traditional Chinese Medicine,Wuhan Hubei 430015,China;School of Basic Medicine,North China University of Science and Technology,Tangshan Hebei 063000,China;Department of Radiology,The First Clinical Medical College of China Three Gorges University/Yichang Central People's Hospital,Yichang Hubei 443000,China)
出处
《临床和实验医学杂志》
2022年第23期2555-2558,共4页
Journal of Clinical and Experimental Medicine
基金
国家自然科学基金(编号:81100282)
湖北中医药大学教育教学研究项目(编号:2021B36)。
