摘要
目的评价不同纳米过滤系统对静注人免疫球蛋白(Intravenous human immunoglobulin,IVIG)的过滤效果,以筛选最佳纳米过滤系统。方法采用不同纳米过滤器进行IVIG过滤,确定最佳纳米过滤器;选用不同预过滤器和优选的纳米过滤器组合,进行IVIG过滤,确定最佳纳米过滤系统。结果切向流(错流)纳米过滤器过滤效果优于死端(直流)纳米过滤器,纳米过滤器C为最佳纳米过滤器;深层过滤预过滤器的过滤效果优于绝对过滤预过滤器,预过滤器Y1串联纳米过滤器C为最佳纳米过滤系统。结论通过不同纳米过滤系统对IVIG过滤效果的评价,筛选出了最佳纳米过滤系统。
Objective To evaluate the filtration effects of various nanofiltration systems on intravenous human immunog-lobulin(IVIG)in order to screen the optimal nanofiltration system.Methods Various nanofilters were used for IVIG filtration to determine the best one and then various prefilters were selected to combine with the optimal nanofilter for IVIG filtration to determine the optimal nanofiltration system.Results The tangential flow(cross flow)nanofilter showed better filtering effect than dead end(direct current)nanofilter,and nanofilter C was the best one.The effect of deep filtration prefilter was better than that of absolute filtration prefilter,and prefilter Y1 in series with nanofilter C was the optimal nanofiltration system.Conclusion The optimal nanofiltration system was determined through the effect evaluation of various nanofiltration systems filtering for IVIG.
作者
马力
李冠军
张学成
范蓓
马小伟
王志刚
MA Li;LI Guan-jun;ZHANG Xue-cheng;FAN Bei;MA Xiao-wei;WANG Zhi-gang(Research and Development Center,Hualan Biological Engineering Inc.,Xinxiang 453003,Henan Province,China)
出处
《中国生物制品学杂志》
CAS
CSCD
北大核心
2023年第1期81-84,共4页
Chinese Journal of Biologicals
基金
国家科技重大专项(2012ZX09201301)。
关键词
静注人免疫球蛋白
预过滤
纳米膜过滤
Intravenous human immunoglobulin(IVIG)
Prefiltration
Nanofiltration
