摘要
猪流行性腹泻病毒(PEDV)是冠状病毒科甲型冠状病毒属的一种有囊膜的单股正链RNA病毒,对全世界养猪业造成了巨大的损失。PEDV与宿主之间的致病机制和免疫调节相互作用仍不清楚。有研究表明冠状病毒可以诱导细胞发生自噬,并且与病毒的复制有着密切的联系,病毒与细胞自噬之间的关系十分复杂,虽然病毒感染与细胞自噬之间的关系研究比较广泛,但细胞自噬在PEDV感染中的作用报道较少。研究PEDV与细胞自噬的相互作用可以加速对PEDV感染入侵机制的理解,为未来研究病毒治疗和抗病毒药物提供新的思路。
Porcine epidemic diarrhea virus(PEDV) is a single-stranded plus-stranded RNA virus with capsule belonging to the genes A coronavirus.It has caused great losses to pig industry in the world.The pathogenesis and immunomodulatory between PEDV and the host are still largely unknown.Studies reveal that coronaviruses can induce autophagy in cells and are closely related to virus replication.The relationship between virus and autophagy is very complex.Although studies on the relationship between virus infection and autophagy are extensive,there are few reports on the role of autophagy in PEDV infection.Studying the interaction between PEDV and autophagy can accelerate our understanding of the invasion mechanism of PEDV infection and provide new ideas for future research on viral therapy and antiviral drugs.
作者
蓝小媛
徐瑶
张伟
高崧
郇长超
LAN Xiaoyuan;XU Yao;ZHANG Wei;GAO Song;HUAN Changchao(Yangzhou University,College of Veterinary Medicine,Yangzhou,Jiangsu Province 225009,China)
出处
《中国饲料》
北大核心
2023年第3期1-4,共4页
China Feed
