摘要
目的:观察知柏地黄汤加减联合西药治疗小儿过敏性紫癜阴虚火旺证的临床疗效。方法:采用随机数字表法将86例过敏性紫癜患儿分为对照组与观察组各43例。对照组给予常规西药治疗,观察组采用常规西药联合知柏地黄汤加减治疗。比较2组治疗前后中医证候评分、T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD19^(+))、免疫球蛋白、炎症因子水平。比较2组临床疗效及复发情况。结果:治疗后,观察组总有效率为93.02%,显著高于对照组74.42%(P<0.05)。治疗后,2组皮肤紫癜、关节疼痛、腹痛、手足心热、两面颧红、低热盗汗、心烦少寐评分均较治疗前降低(P<0.05),且观察组中医证候评分低于对照组(P<0.05)。治疗后,2组血清CD3^(+)、CD4^(+)水平较治疗前升高(P<0.05),CD19^(+)水平降低(P<0.05),且观察组上述指标改善优于对照组(P<0.05);2组血清免疫球蛋白A (IgA)、免疫球蛋白M (IgM)、免疫球蛋白G (IgG)、肿瘤坏死因子-α (TNF-α)、白细胞介素-4 (IL-4)、白细胞介素-12 (IL-12)水平均较治疗前降低(P<0.05),且观察组免疫球蛋白及炎症因子水平均低于对照组(P<0.05)。随访3个月后,观察组复发率12.50%,低于对照组40.62%(P<0.05)。结论:知柏地黄汤加减联合西药治疗过敏性紫癜临床疗效显著,能够有效提高患儿免疫水平,降低炎症因子水平及复发率。
Objective:To observe the clinical effect of the therapy of modified Zhibai Dihuang Tang combined with western medicine on children with allergic purpura with syndrome of vigorous fire due to yin deficiency.Methods:A total of 86 children with allergic purpura were randomly divided into the observation group and control group,with 43 cases in each group.The control group was treated with conventional western medicine,and the observation group was additionally treated with conventional western medicine combined with modified Zhibai Dihuang Tang.The Chinese medicine syndrome scores,T lymphocyte subsets,including CD3^(+),CD4^(+),and CD19^(+),immunoglobulin and inflammatory factors were compared between the two groups before and after treatment.The clinical effects and recurrence were compared between the two groups.Results:After treatment,the observation group total effective rate was 93.02%were higher than control group 74.42%(P<0.05).After treatment,the scores of skin purpura,joint pain,abdominal pain,fever of palms and sole,hot flushes on the cheeks,low-grade fever and night sweats,vexation and restless sleep in the two groups were lower than those pre-treatment(P<0.05),and the scores of the above Chinese medicine syndromes in the control group were higher than those in the observation group(P<0.05).After treatment,compared with pre-treatment the serum levels of CD3^(+)and CD4^(+)in the two groups were increased(P<0.05),but the levels of CD19^(+)were decreased(P<0.05),and the improvement of the above levels in the observation group was better than that in the control group(P<0.05);compared with those pre-treatment,the serum levels of immunoglobulin A(IgA),immunoglobulin M(IgM),immunoglobulin G(IgG),tumor necrosis factor-α(TNF-α),interleukin-4(IL-4) and interleukin-12(IL-12) were significantly decreased(P<0.05);in the control group the levels of immunoglobulin and inflammatory factors were higher than those in the observation group(P<0.05).After three months of follow-up,the observation group recurrence rate was 1
出处
《新中医》
CAS
2022年第23期43-47,共5页
New Chinese Medicine
关键词
小儿过敏性紫癜
阴虚火旺
知柏地黄汤
免疫球蛋白
白细胞介素
Children with allergic purpura
Vigorous fire due to yin deficiency
Zhibai Dihuang Tang
Immunoglobulin
Interleukin
