摘要
目的了解2018—2021年北京市3家医院乙型肝炎病毒(hepatitis B virus,HBV)感染患者的血清学检测指标特征。方法收集北京市3家医院2018—2021年的HBsAg阳性HBV感染患者的乙肝五项、肝功能、HBV DNA载量、AFP和PT检测结果及基本临床信息,采用SAS 9.4统计学软件分析HBV感染患者的疾病诊断、乙肝五项血清学指标阳性模式和临床特征情况。结果2018—2021年北京市3家医院进行乙肝五项或乙肝表面抗原定量(HBsAg-QN)检测的1026604例就诊患者中,HBsAg阳性检出率为53.50%,其HBsAg每年的阳性检出率依次为57.22%、55.05%、53.64%和47.69%,呈逐年下降趋势。111709例乙肝患者同时进行了乙肝五项、肝功能、HBV DNA载量、AFP和PT检测,将其按年龄分为1~30岁组、31~60岁组和>60岁组,3组HBV感染患者主要疾病为慢性乙型病毒性肝炎(chronic hepatitis B,CHB),其急性乙型肝炎(acute hepatitis B,AHB)和CHB的患者比例随着年龄的增长呈下降趋势,而HBV相关性肝硬化、HBV相关性肝癌及肝癌术后和肝移植术后的患者比例随着年龄增长呈上升趋势,差异均具有统计学意义(均P<0.05)。本研究中乙肝五项血清学指标阳性模式共检测出24种,包括常见模式7种(主要模式为145模式)、少见模式14种(主要模式为1345模式)和罕见模式3种(主要模式为12345模式)。本研究中HBsAg阳性组(90011例)患者的年龄、男性比例、HBeAg阳性检出率、HBV DNA阳性检出率及载量、TBIL、ALT、AFP及PT结果均高于HBsAg阴性组(21698例),且两组HBV感染患者结果都高于健康对照组(20623例);ALB检测结果为HBsAg阳性组最低而健康对照组最高,差异均具有统计学意义(均P<0.05)。结论2018—2021年北京市3家医院进行乙肝五项或HBsAg-QN检测的就诊者中,HBsAg阳性检出率逐年下降;年龄与HBV感染患者疾病进展相关;HBV感染者乙肝五项血清学指标阳性模式呈现多样性。
Objective To understand the characteristics of serological detection indicators of patients with hepatitis B virus(HBV)infection in three hospitals in Beijing from 2018 to 2021.Methods The five markers of hepatitis B,liver function tests,HBV DNA load,AFP and PT test results and basic clinical information of HBsAg positive HBV infected patients in three hospitals in Beijing from 2018 to 2021 were collected.Then the diagnosis of HBV infection,the positive patterns of serological indicators for five markers of hepatitis B and the clinical characteristics of hepatitis B patients were analyzed by SAS 9.4 statistical software.Results Among the 1026604 patients who were tested for the five markers of hepatitis B or hepatitis B surface antigen quantification(HBsAg-QN)in three hospitals in Beijing from 2018 to 2021,the positive detection rate of HBsAg was 53.50%.The annual positive detection rate of HBsAg was 57.22%,55.05%,53.64%and 47.69%successively,showing a downward trend year by year.111709 hepatitis B patients were divided into 1-30,31-60 and>60 years old groups according to their age.The main diseases of the three groups of HBV infected patients was chronic hepatitis B(CHB),and the proportion of patients with acute hepatitis B(AHB)and CHB decreased with age,while the proportion of patients with HBV-related liver cirrhosis,HBV-related liver cancer,liver cancer surgery and liver transplantation increased with age,the difference of which was statistically significant(all P<0.05).In this research,a total of 24 positive patterns of the five markers of hepatitis B were detected,including 7 common patterns(the main pattern was 145),14 rare patterns(the main pattern was 1345),and 3 unusual patterns(the main pattern was 12345).The age,male ratio,HBeAg positive detection rate,HBV DNA positive detection rate and load,TBIL,ALT,AFP and PT results in the HBsAg positive group(90011cases)were higher than those in the HBsAg negative group(21698 cases),and the above results of the two groups of hepatitis B patients were higher than
作者
卞成蓉
刘新
刘娟
宋英伟
宋丽娟
周俊
杨瑞锋
娄金丽
李伯安
Bian Chengrong;Liu Xin;Liu Juan;Song Yingwei;Song Lijuan;Zhou Jun;Yang Ruifeng;Lou Jinli;Li Bo′an(Department of Clinical Laboratory,the Fifth Medical Center,Chinese People′s Liberation Army(PLA)General Hospital,Beijing 100039,China;Clinical Laboratory Center,Beijing You′an Hospital,Capital Medical University,Beijing 100069,China;Sansure Biotechnology Corporation,Changsha 410221,China;Department of Blood Transfusion Medicine,the First Medical Center,Chinese PLA General Hospital,Beijing 100853,China;Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China;Peking University People′s Hospital,Peking University Hepatology Institute,Beijing 100044,China;School of Medical Laboratory,Weifang Medical University,Weifang 261053,China;Department of Laboratory Medicine,School of Medical Technology and Engineering,Fujian Medical University,Fuzhou 350122,China)
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
2022年第6期629-636,共8页
Chinese Journal of Experimental and Clinical Virology
基金
19SWAQ06
北京市优秀人才培养青年骨干个人项目(2018000021469G287)。
