摘要
目的 探讨胃肠道双向分化癌的临床病理特点、分级及鉴别诊断。方法 回顾性分析2例双向分化癌患者的临床病理资料,并复习相关文献。结果 2例患者均行根治性手术治疗,例1以腺样、巢片状生长伴黏液产生,例2在黏液背景中呈印戒细胞样生长。2例均可见细胞内外黏液,细胞核染色质细腻,且免疫组织化学表达腺和神经内分泌标记,证明其具有双向分化特征。2例病例高级别肿瘤成分均> 75%,分级均为3级。结论 双向分化癌是一种具有双向分化特征的恶性肿瘤,诊断主要依赖组织学形态及免疫组织化学检测。
Objective To investigate the clinicopathological characteristics, grading and the differential diagnosis of gastrointestinal amphicrine carcinoma. Methods The clinicopathologic features of two case of gastrointestinal amphicrine carcinoma were retrospectively analyzed and relative literature was reviewed. Results Radical surgery was performed in both cases. Case 1 mainly had glandular tubular structure and nest-like growth with mucus, and case 2 had signet ring-like cells in mucus. In both cases, intracellular and extracellular mucus was seen, the nuclear chromatin was delicate, and neuroendocrine markers were expressed by immunohistochemistry, which proved that they had the characteristics of amphoteric differentiation. Both cases had high-grade tumor components>75%, and both were grade 3. Conclusion Amphicrine carcinoma is a malignant tumor with amphoteric differentiation, and its diagnosis mainly depends on histological morphology and immunohistochemical detection.
作者
杨钰斌
吴春林
Yang Yubin;Wu Chunlin(Department of Pathology,The Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,China)
出处
《中国组织化学与细胞化学杂志》
CAS
CSCD
2022年第6期604-607,共4页
Chinese Journal of Histochemistry and Cytochemistry
