摘要
目的分析调治银屑病中药复方专利用药规律,为中药新药研发、专利保护提供指导。方法计算机检索国家知识产权局中国专利公布公告网站建库至2022年3月4日调治银屑病的中药复方专利数据,对药物使用频次、性味归经等进行描述性统计分析,采用SPSS Modeler 18.0、Cytoscape3.8.0软件对高频药物间关联规则和复杂网络进行分析和展示,采用SPSS Statistics 26.0软件对高频药物进行系统聚类分析。结果纳入中药复方专利292项,涉及药物830味。最常见的主治证候为血热证(84次,28.77%),常用药物前10位依次为生地黄(121次,41.44%)、白鲜皮(112次,38.36%)、甘草(106次,36.30%)、牡丹皮(99次,33.90%)、赤芍(95次,32.53%)、当归(93次,31.85%)、苦参(88次,30.14%)、土茯苓(85次,29.11%)、金银花(78次,26.71%)、紫草(76次,26.03%),使用频次最高的是寒性药物、苦味药物和归肝经药物。得到强关联对药9组,强关联角药7组,高置信度关联规则有白鲜皮-地肤子→牡丹皮、白鲜皮-地肤子→苦参等;核心药物为白鲜皮、生地黄等;聚类分析得到新处方有“白鲜皮、地肤子、苦参、牡丹皮、赤芍、生地黄”,“乌梢蛇、蝉蜕、防风、荆芥、薏苡仁”等。结论临床研发调治银屑病中药复方可针对其常见主治证候,活用清热、凉血、活血、祛瘀、利湿、补虚之品,以提高临床疗效。
Objective To provide guidance for the research and development of new TCM and patent protection through analyzing the medication law of TCM compound patents for the regulation and treatment of psoriasis.Methods Patent data of TCM compounds for the treatment of psoriasis were retrieved from State Intellectual Property Office China Patent Publication Announcement Website from establishment to March 4,2022.Descriptive statistical analysis was conducted for the cumulative frequency,properties and tastes,and meridians of drugs,etc.SPSS Modeler 18.0 and Cytoscape 3.8.0 software were used to analyze and display high-frequency drug association rules and complex networks.SPSS Statistics 26.0 software was used to conduct systematic cluster analysis on high-frequency drugs.Results Totally 292 TCM compound patents were included in the study,involving 830 kinds of Chinese materia medica.The most common syndrome was blood-heat syndrome(84 times,28.77%).The top 10 most commonly used medicines in order were Rehmannine Radix(121 times,41.44%),Dictamni Cortex(112 times,38.36%),Glycyrrhizae Radix et Rhizoma(106 times,36.30%),Moutan Cortex(99 times,33.90%),Paeoniae Radix Rubra(95 times,32.53%),Angelicae Sinensis Radix(93 times,31.85%),Sophorae Flavescentis Radix(88 times,30.14%),Smilacis Glabrae Rhizoma(85 times,29.11%),Lonicerae Japonicae Flos(78 times,26.71%),Arnebiae Radix(76 times,26.03%).The most frequently used were cold medicines,bitter medicines and liver meridian medicines.In addition,there were 9 strongly associated medicinal groups of pair medicine and 7 strongly associated groups of triple medicine.High confidence correlateion patterns included Dictamni Cortex-Kochiae Fructus→Moutan Cortex,Dictamni Cortex-Kochiae Fructus→Sophorae Flavescentis Radix.The core medicines were Dictamni Cortex,Rehmannine Radix.Finally,the new prescriptions obtained from cluster analysis were“Dictamni Cortex,Kochiae Fructus,Sophorae Flavescentis Radix,Moutan Cortex,Paeoniae Radix Rubra,Rehmannine Radix”,“Zaocys,Cicadae Periostracum,Sa
作者
成雪
刘朝圣
刘芳榕
程晓
周兴
CHENG Xue;LIU Chaosheng;LIU Fangrong;CHENG Xiao;ZHOU Xing(The First Hospital of Hunan University of Chinese Medicine,Changsha 410007,China)
出处
《中国中医药信息杂志》
CAS
CSCD
2023年第2期62-67,共6页
Chinese Journal of Information on Traditional Chinese Medicine
基金
国家自然科学基金面上项目(82074444)
湖南省卫生健康委科学研究课题(20201181)
国医大师熊继柏传承工作室开放基金(XJB202201)。
关键词
银屑病
专利
配伍规律
中药复方
psoriasis
patents
compatibility rules
TCM compounds
