摘要
口腔鳞状细胞癌是最常见的口腔恶性肿瘤,研究口腔鳞状细胞癌的光学成像对其大规模筛查和手术精准切除有重要意义,有助于实现口腔鳞状细胞癌的早期发现并提高手术患者的生存率和生存质量。本文就鲁戈氏碘染色、甲苯胺蓝染色、亚甲基蓝染色、化学发光成像、光学相干断层成像、拉曼光谱成像、组织自发荧光成像、窄带成像、5-ALA诱导的原卟啉IX荧光成像、吲哚菁绿近红外荧光成像和靶向分子荧光成像在口腔鳞状细胞癌光学成像技术方面的临床研究进展进行综述。
Oral squamous cell carcinoma is the most common oral malignant tumor.The study of optical imaging is of great significance for large-scale screening and precise surgical resection,which is helpful to realize early detection of oral squamous cell carcinoma and improve the survival rate and quality of life of patients undergoing surgery.In this paper,we review the clinical research progress in optical imaging of oral squamous cell carcinoma including Lugol’s iodine staining,toluidine blue staining,methylene blue staining,chemiluminescence imaging,optical coherence tomography imaging,Raman spectrum imaging,tissue autofluorescence imaging,narrow band imaging,fluorescence imaging of protoporphyrin IX induced by 5-aminolevulinic acid,indocyanine green near-infrared fluorescence imaging and targeted molecular fluorescence imaging.
作者
田瑜
靳能皓
朱亮
胡随馨
周正
张海钟
TIAN Yu;JIN Nenghao;ZHU Liang;HU Suixing;ZHOU Zheng;ZHANG Haizhong(Chinese PLA Medical School,Beijing 100039,China;Department of Stomatology,the First Medical Center,Chinese PLA General Hospital,Beijing 100039,China;Department of Stomatology,the 980th Hospital of the Joint Logistics Support Force of Chinese PLA,Shijiangzhuang 061011,Hebei Province,China)
出处
《解放军医学院学报》
CAS
北大核心
2022年第12期1298-1305,共8页
Academic Journal of Chinese PLA Medical School
基金
军队后勤科研重大项目(AWS17J004-ZHZ)。
关键词
口腔肿瘤
诊断显像
分子显像
临床研究
近红外荧光
mouth neoplasms
diagnostic imaging
molecular imaging
clinical study
near-infrared fluorescence(NIRF)
