摘要
糖基化是翻译后修饰最重要的方式之一,在生理情况下参与机体的细胞黏附、信号转导、免疫调节等各项生命活动。卵巢癌是继乳腺癌、宫颈癌后威胁女性生殖健康的第三大恶性肿瘤,其发生发展伴随异常糖基化修饰。异常的糖基化与肿瘤生长、逃避细胞凋亡、侵袭迁移及治疗抵抗等密切相关,其中唾液酸化和岩藻糖基化表达上调是最常见的异常糖基化修饰类型,本文通过阐释卵巢癌中异常唾液酸化和岩藻糖基化的研究进展,发现其对促进卵巢癌的早期诊断、预测预后、靶向治疗等具有重要临床意义。
Glycosylation is one of the most important ways of post-translational modification,and participates in va-rious activities such as cell adhesion,signal transduction,and immune regulation under physiological conditions.Ovar-ian cancer is the third largest malignant tumor threatening female reproductive health after breast cancer and cervical cancer.It's occurrence and development are accompanied by abnormal glycosylation modifications.Abnormal glycosy-lation is closely related to tumor growth,evasion of apoptosis,invasion and migration,and resistance to therapy.The up-regulation of sialylation and fucosylation are the most common types of abnormal glycosylation.The research pro-gress of abnormal sialylation and fucosylation in ovarian cancer has important clinical significance for promoting early diagnosis,prognosis prediction and targeted therapy of ovarian cancer.
作者
蒲从丽
赵迎超
PU Congli;ZHAO Yingchao(Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Hubei Wuhan 430000,China)
出处
《现代肿瘤医学》
CAS
北大核心
2023年第3期561-566,共6页
Journal of Modern Oncology
基金
国家自然科学基金(编号:81974463)。
