摘要
目的对比口服复方血栓通胶囊联合视网膜光凝与玻璃体腔注射雷珠单抗联合视网膜光凝和口服复方血栓通胶囊治疗视网膜分支静脉阻塞合并黄斑水肿的治疗效果。方法回顾性分析确诊为视网膜分支静脉阻塞合并黄斑水肿的42例患者42眼,按不同治疗方案分为2组:试验组(21眼)为玻璃体腔注射雷珠单抗联合复方口服血栓通胶囊和视网膜光凝治疗组,对照组(21眼)为复方血栓通联合视网膜激光光凝治疗组。试验组先行雷珠单抗玻璃体腔注射,同时口服复方血栓通胶囊,3个月后行视网膜激光光凝;对照组行视网膜光凝和口服复方血栓通胶囊。观察治疗6个月2组患者的最佳矫正视力,黄斑中心凹视网膜厚度变化。结果治疗6个月后2组最佳矫正视力均提高,试验组优于对照组;眼科光学相干断层扫描显示试验组黄斑中心凹厚度平均降低415.51μm(61.45%),对照组黄斑中心凹厚度平均降低120.51μm(27.40%),试验组优于对照组。结论玻璃体腔注射雷珠单抗联合口服复方血栓通胶囊和视网膜光凝治疗视网膜分支静脉阻塞合并黄斑水肿安全有效。
Objective To compare the therapeutic effect of oral compound thrombolysis capsules combined with retinal photocoagulation,intravitreal injection ranibizumab and oral compound thrombolysis capsules combined with retinal photocoagulation in the treatment of retinal branch vein occlusion and macular edema.Methods A retrospective analysis was conducted in 42 patients with 42 eyes diagnosed with retinal branch vein occlusion and macular edema,and the patients were divided into two groups according to different treatment regimens:the experimental group(21 eyes)was treated with intravitreal injection ranibizumab combined with compound oral thrombolysis capsules and retinal photocoagulation,the control group(21 eyes)was given the compound thrombolysis capsule combined with retinal laser photocoagulation,the experimental group received ranibizumab intravitreal injection,while oral thrombolysis capsule,and retinal laser photocoagulation was performed 3 months later.The two groups underwent simple retinal photocoagulation and oral thrombosis capsules.The optimal corrected visual acuity of the two groups was examined during the 6-month treatment period,the changes of macular foveal retinal thickness were determined.Results After 6 months of treatment,the optimal corrected visual acuity of both groups was improved,and the treating effects of the experimental group was better than that of the control group,and the ophthalmic optical coherence tomography showed that the macular foveal thickness was reduced by 415.51μm(61.45%)in the combination treatment group and 120.51μm(27.40%)in the control group,which indicated that the treating effects of the experimental group was better than that of the controls.Conclusion Intravitreal injection of ranibizumab combined with oral compound thrombolysis capsule and retinal photocoagulation is safe and effective in the treatment of retinal branch vein occlusion and macular edema.
作者
张虎
郝建章
齐峰
冯玮
王青
ZHANG Hu;HAO Jianzhang;QI Feng;FENG Wei;WANG Qing(Department of Ophthalmology,Baoding NO.1 Hospital,Baoding 071000,China)
出处
《医学研究与教育》
CAS
2022年第6期24-28,共5页
Medical Research and Education
基金
保定市科学技术研究与发展计划项目(2041ZF054)。
关键词
雷珠单抗
复方血栓通胶囊
视网膜光凝
视网膜分支静脉阻塞
黄斑水肿
ranibizumab injections
compound thrombolysis capsule
retinal photocoagulation
retinal vein embolism
macular edema
