摘要
芫菁科昆虫斑蝥(Mylabris)是我国经典大毒抗肿瘤中药之一,斑蝥素(cantharidin,CTD)是其主要活性成分。因其具有独特的升白提高免疫的优势,斑蝥素类上市中药大品种已成为目前临床联合化疗的主流用药。然而,民间常因为误食、多食频发斑蝥中毒事件,临床应用也常出现不良反应,尤其是肝、肾毒性。其靶器官损伤机制尚不十分清楚,极大地制约了其临床应用,因此亟须厘清斑蝥病理损伤及毒理机制。本文对近年来斑蝥致肝、肾毒性研究进行综述,探析其共性毒性规律、毒理机制及减毒保护策略,以期为斑蝥的减毒策略及新药研发提供参考。
Mylabris, a classical anti-tumor traditional Chinese medicine, belongs to insect of the Coriolus family. Cantharidin(CTD) is the main active ingredient of Mylabris, with the unique advantages of promoting apoptosis of tumor cells and enhancing immune function by elevating the number of leukocytes. It has been used as a classical drug with combination of chemotherapy. However, there are frequent cases of Mylabris poisoning due to accidental ingestion, polyphagia and clinical application. Its severe toxic effects cannot be ignored, especially in nephrotoxicity and hepatoxicity. The mechanism of target organ injury is not very clear, which greatly restricts its clinical application. Therefore, there is an urgent need to clarify the toxic pathological damage, toxic mechanism. In this paper, the recent studies on the hepatotoxicity and nephrotoxicity of Mylabris were reviewed, and the general toxicity rule, toxicological mechanism and detoxification protection strategy were analyzed, so as to provide reference for the detoxification strategy of Mylabris and the research and development of new drugs.
作者
何天目
张建永
刘流
李晓飞
HE Tianmu;ZHANG Jianyong;LIU Liu;LI Xiaofei(Zunyi Medical University,School of Preclinical Medicine,Zunyi 563000,China;Zunyi Medical University,School of Pharmacy,Zunyi 563000,China;School of Basic Medicine,Guizhou Medical University,Guiyang 550025,China)
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2022年第24期3310-3315,共6页
Chinese Journal of Modern Applied Pharmacy
基金
国家自然科学基金项目(82060754,81803838)
遵义市优秀青年科技创新人才培养项目(遵优青科[2021]3号)。
关键词
斑蝥
机制
肝毒性
肾毒性
Mylabris
mechanism
hepatoxicity
nephrotoxicity
