摘要
目的探讨基因HLA-A rs3132682的单核苷酸多态性与肝癌发病风险的关系。方法选择延边地区291例肝癌患者为实验组,另选健康人272例为对照组,通过病例对照研究方法进行研究。利用MassARRAY SNPS质谱法检测两位点的基因型及等位基因分布频率。通过非条件Logistic回归计算比值比(OR)及95%可信区间(CI),评估携带不同基因型人群发生肝癌的风险度。结果HLA-A rs3132682位点包括G和C两种等位基因,GG、GC和CC基因型;在HLA-A rs3132682位点中校正混杂因素后,经非条件Logistic回归分析,与携带GG基因型人群相比,携带CC基因型人群与患肝癌风险有明显相关性(P<0.05)。分层分析显示:与携带CG+GG基因型人群相比,携带CC基因型朝鲜族人群增加3.331倍肝癌患病风险。结论HLA-A rs3132682位点单核苷酸多态性与延边地区患肝癌风险存在明显相关性。
Objective To study the relationship between the single nucleotide polymorphism of HLA-A rs3132682 and the risk of liver cancer.Methods The author selected 291 cases of liver cancer patients in Yanbian area as the experimental group and 272 healthy people as the control group.The genotypes and allele frequencies of the two loci were detected by MassARRAY SNPS mass spectrometry.Odds ratio(OR)and 95%confidence interval(CI)were calculated by unconditional logistic regression to evaluate the risk of liver cancer in patients with different genotypes.Results There were G and C alleles in HLA-A rs3132682 locus,GG,GC and CC genotype.After adjusting for confounding factors in HLA-A rs3132682 locus,there was correlation between CC genotype and the risk of liver cancer compared with GG genotype(P<0.05).Stratification analysis showed that compared with the population with CG+GG genotype,the Korean population with CC genotype increased the risk of liver cancer by 3.331 times.Conclusion The single nucleotide polymorphism ofHLA-Ars3132682 is correlated with the risk of liver cancer in Yanbian area.
作者
刘霞
崔鹤松
白雪
崔英
孙紫洋
金光
Liu Xia;Cui Hesong;Bai Xue;Cui Ying;Sun Ziyang;Jin Guang(Laboratory of Pathology and Pathophysiology of Yanbian University,Yanji 133002;Dept of Infection,Affiliated Hospital of Yanbian University,Yanji 133002)
出处
《安徽医科大学学报》
CAS
北大核心
2023年第1期156-161,共6页
Acta Universitatis Medicinalis Anhui
基金
国家自然科学基金(编号:31460284)
吉林省科技厅重点攻关项目(编号:20170204037YY)。
关键词
肝癌
单核苷酸多态性
易感性
liver cancer
single nucleotide polymorphism
susceptibility
