摘要
随着老龄化社会的到来,心脑血管疾病越来越多,造影检查及介入治疗成为心脑血管疾病的主要诊断及治疗手段,而造影剂引起的急性肾损伤随之而来,可导致不良预后,严重可致急性肾衰竭,因此预防造影后急性肾损伤具有积极意义。尼可地尔是腺嘌呤核苷三磷酸敏感的钾离子通道开放剂,可改善心脏微血管循环,这种钾离子通道除了存在于冠脉血管中,也存在于肾脏血管中,因此推断尼可地尔可以扩张肾动脉,增加肾血流,从而对预防造影后急性肾损伤有一定的作用。本文就造影后急性肾损伤及发病机制、尼可地尔对造影后急性肾损伤的预防进行综述,从而指导临床用药。
With the coming of aging society,there are more and more cardiovascular and cerebrovascular diseases.Angiographic examination and interventional therapy have become the main means of diagnosis and treatment of cardiovascular and cerebrovascular diseases.With the advent of acute renal injury caused by contrast agents,it can lead to poor prognosis and serious acute renal failure.Therefore,it is essential to prevent acute renal injury after angiography.Nicorandil is adenine triphosphate(ATP)sensitive potassium channel,which can improve the microvascular circulation of heart vessels.This potassium channel exists in both coronary arteries and renal vessels.Therefore,we infer that Nicorandil can dilate renal arteries,increase renal blood flow,and thus play a certain role in preventing acute renal injury after angiography.This article reviews the acute renal injury after angiography and its pathogenesis,and the prevention of acute renal injury after angiography by nicorandil,so as to guide clinical medication.
作者
王倩倩
WANG Qianqian(Department of Cardiology,The Third People’s Hospital of Jinan,Jinan,Shandong 250100,China)
出处
《医药前沿》
2022年第31期47-49,共3页
Journal of Frontiers of Medicine
基金
《尼可地尔对急性ST段抬高型心肌梗死急诊经皮冠状动脉介入治疗术后血流动力学、心功能及临床预后的影响》(2020-4-39)。
关键词
综述
造影后急性肾损伤
尼可地尔
预防作用
Review
Acute renal injury after angiography
Nicorandil
Preventive effect【】
