摘要
近年来核调控作为病原微生物感染宿主细胞的调控机制研究备受关注。病原体分泌“核调素”与宿主细胞核相关靶点相互作用,通过调节细胞核内与基因表达相关的特定生命活动实现感染和致病。其过程包括染色质动力学改变、组蛋白修饰、DNA甲基化、mRNA剪切、细胞周期和信号通路转导等。本文综述了病毒、细菌及寄生虫等病原微生物对宿主细胞核调控的主要策略及研究进展,特别是调控染色质可及性、改变宿主DNA的一级结构和甲基化水平、调控宿主hnRNA的生成和剪切等机制,以期为深入研究病原微生物感染免疫机制提供新思路。
In recent years,nuclear regulation has attracted much attention as a regulatory mechanism of host cell infection by pathogenic microorganisms.The pathogen-secreted nucleomodulins interact with the relevant targets in the host cell nucleus,and induce infection and pathogenesis by regulating specific life activities related to gene expression in the nucleus.The process involves chromatin dynamic changes,histone modification,DNA methylation,mRNA cleavage,cell cycle and signal transduction.In this review,in order to provide novel insights into the immune mechanism of pathogenic microbial infection,we discussed the research progress in the regulation of host cell nucleus by pathogenic microorganisms such as viruses,bacteria and parasites,and particularly investigated the mechanisms of regulating chromatin accessibility,changing the primary structure and methylation level of host DNA,and regulating the generation and cleavage of host hnRNA.
作者
吴潘
南栋琪
饶承龙
李倩
毛旭虎
WU Pan;NAN Dong-qi;RAO Cheng-long;LI Qian;MAO Xu-hu(Department of Clinical Microbiology and Immunology,College of Pharmacy and Medical Laboratory,Army Medical University,Chongqing 400038,China)
出处
《中国病原生物学杂志》
CSCD
北大核心
2022年第12期1484-1488,共5页
Journal of Pathogen Biology
基金
国家自然科学基金项目(No.31970135,81971907)。
关键词
核调控机制
核调素
病原微生物
细胞微生物学
综述
nuclear regulatory mechanism,nucleomodulins,pathogenic microorganisms,cellular microbiology
review
