摘要
目的:综述近十年来中医药介导线粒体影响癫痫的实验研究进展,旨在为临床从线粒体结构、功能失态及中医药影响癫痫方面提供较客观及科学的实验研究支持,进一步指导临床抗癫痫发作的治疗。方法:以线粒体、癫痫、中医药作为重点词检索PubMed、中国期刊全文数据库及万方数据库中近年来中医药介导线粒体影响癫痫的相关实验研究文献。结果:中医药可通过线粒体结构、ATP酶活性、线粒体复合体活性、线粒体膜电位、线粒体凋亡相关信号等相关线粒体靶点保护神经细胞,改善模型动物癫痫发作症状。结论:中医药可以通过介导线粒体而影响癫痫发作。
Objective:To review the progress of the experimental study on mitochondria mediated by traditional Chinese medicine on epilepsy in the recent ten years,so as to provide more objective and scientific experimental research support for clinical work from mitochondrial function,dysfunction and the influence of TCM on epilepsy,and further guide clinical antiepileptic treatment.Methods:The literature related to experimental research of the effects of TCM-mediated mitochondria on epilepsy in the recent years was searched from PubMed,CNKI and WanFang by taking mitochondria,epilepsy and TCM as the key words.Results:TCM could protect nerve cells and improve the symptoms of animal models suffering the seizure via the associated mitochondrial targets including mitochondrial function,the activity of ATP enzyme,the activity of mitochondrial complex,mitochondrial membrane potential,mitochondrial apoptosis-related signals.Conclusion:TCM could affect the epileptic seizure through mediating mitochondria.
作者
莫穷泽
何乾超
高玉广
黄丽蓉
邓惠
庞东林
林洁洁
田方
MO Qiongze;HE Qianchao;GAO Yuguang;HUANG Lirong;DENG Hui;PANG Donglin;LIN Jiejie;TIAN Fang(Guangxi University of Chinese Medicine,Nanning 530001,China;The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,China)
出处
《西部中医药》
2023年第1期136-139,共4页
Western Journal of Traditional Chinese Medicine
基金
广西自然科学基金面上项目(2019JJA140204)
广西卫生和计划生育委员会医疗卫生适宜技术研究与开发项目(S2018099)
广西中医药大学校级科研项目(2019MS015)。
关键词
癫痫
线粒体
中医药
综述
epilepsy
mitochondria
TCM
review
