摘要
白塞综合征(Behcet’s syndrome,BS)是一种慢性复发性血管炎,以复发性口腔溃疡、生殖器溃疡、眼部病变和皮肤损伤为特征,可累及多个器官系统。累及胃肠道的BS称为肠白塞综合征,可导致严重并发症甚至死亡。肠白塞综合征的发病机制尚未完全阐明,近年来多项研究聚焦于BS患者的肠道受累群体,发现多种基因与BS肠道受累相关,多种免疫细胞和免疫分子异常,受累肠道黏膜上皮屏障及免疫屏障功能受损。本文从遗传易感、免疫异常和肠道稳态失调三个方面对肠白塞综合征发病机制的最新进展进行综述,以期为该病治疗提供参考。
Behcet’s syndrome(BS)is a chronic recurrent vasculitis characterized by recurrent oral ulcers,genital ulcers,ocular lesions,and skin lesions.Multiple organs and systems could be involved in BS patients.Gastrointestinal involvement in BS is called intestinal BS which is associated with severe complications leading to significant morbidity and mortality.However,the pathogenesis of intestinal BS has not been fully elucidated.In recent years,several studies have focused on the intestinal BS population,finding the relationship between multiple genes and intestinal involvement,changes in various immune cells and molecules,and abnormalities in epithelial and immune barriers of affected mucosa.In this article,we review the cutting-edge new researches on the pathogenesis of intestinal BS from genetic susceptibility,immune dysfunction,and gut homeostasis disorder.
作者
闫夏晓
吴东
YAN Xia-xiao;WU Dong(Department of Gastroenterology,State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)
出处
《中华临床免疫和变态反应杂志》
CAS
2022年第5期499-503,共5页
Chinese Journal of Allergy & Clinical Immunology
基金
国家临床重点专科建设项目(ZK108000)。
关键词
白塞综合征
肠白塞综合征
遗传易感
免疫异常
肠道稳态失调
Behcet’s syndrome
intestinal Behcet’s syndrome
genetic susceptibility
immune dysfunction
gut homeostasis disorder
