摘要
目的探讨角质层含水量与透皮失水率的相关性。方法2021年10月至2022年6月在普宁市公共健康医疗中心、2所幼儿园及2所小学招募≤17岁健康儿童。用皮肤生理功能测量仪测量健康儿童左前臂屈侧和右胫前部位的透皮失水率和角质层含水量,采用Pearson相关分析法分析不同年龄、性别儿童的透皮失水率与角质层含水量的相关性。结果共招募1396例健康儿童,年龄1个月至17岁,男783例、女613例。在1~<12个月组,除男童前臂部位的皮肤透皮失水率与角质层含水量无显著相关性外,男童胫前和女童前臂及胫前部位的透皮失水率与角质层含水量均呈正相关(r值为0.283、0.404、0.420,均P<0.05);在1~2岁组,男童前臂和女童胫前部位的皮肤透皮失水率与角质层含水量无显著相关性,而男童胫前和女童前臂部位的透皮失水率与角质层含水量均呈正相关(r值为0.370、0.419,均P<0.01);在3~5岁组和6~11岁组,除6~11岁组男童胫前的透皮失水率与角质层含水量无显著相关性外,两组男女性其他部位的透皮失水率与角质层含水量均呈显著正相关(r值为0.172~0.293,均P<0.05);12~17岁组,男女性前臂及胫前部位的透皮失水率与角质层含水量均呈显著正相关(r值为0.269~0.485,均P<0.001)。结论健康儿童前臂屈侧和胫前部位的透皮失水率与角质层含水量呈正相关,且随年龄增大,此正相关性有增加趋势。
Objective To determine whether the transepidermal water loss rate(TEWL)is correlated with the stratum corneum(SC)hydration level.Methods Healthy children aged≤17 years were enrolled from Medical Center for Public Health of Puning,2 kindergartens and 2 primary schools,from October 2021 to June 2022.TEWL and SC hydration levels were measured on the left forearm and right anterior shank using a device for measuring skin physiological funcitons.Pearson correlation analysis was used to determine the correlations between TEWL and SC hydration levels in children of different ages and genders.Results A total of 1396 healthy children were enrolled,aged from 1 month to 17 years.Among them,783 were male children and 613 were female children.In children aged 1 to<12 months,no correlation was observed between TEWL and SC hydration levels on the forearms of male children,while TEWL was positively correlated with SC hydration levels on the anterior shanks of male children,as well as on the forearm and anterior shanks of female children(r=0.283,0.404,0.420,respectively,all P<0.05).In children aged 1 to 2 years,positive correlations were observed between the above two indicators on the anterior shanks of male children and forearms of female children(r=0.370,0.419,respectively,both P<0.01),while there were no correlations between the two indicators on the anterior shanks of female children or forearms of male children.Positive correlations were observed between TEWL and SC hydration levels on both the forearms and anterior shanks of female children and the forearms of male children aged 3 to 5 years and 6 to 11 years(r values ranging from 0.172 to 0.293,all P<0.05),but not on the anterior shanks of male children aged from 6 to 11 years.The group aged 12 to 17 years exhibited significantly positive correlations between TEWL and SC hydration levels on both the anterior shanks and forearms of male and female children(r values ranging from 0.269 to 0.485,all P<0.001).Conclusion SC hydration levels are positively correlated with TEWL
作者
赖庆松
陈爱祺
赖宇霖
叶理
王晓华
蔄茂强
Lai Qingsong;Chen Aiqi;Lai Yulin;Ye Li;Wang Xiaohua;Man Maoqiang(Medical Center for Public Health of Puning,Puning 515300,Guangdong,China;Center for Research on Skin Physiology and Development of Skin Care Products,Dermatology Hospital of Southern Medical University,Guangzhou 510091,China)
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2023年第1期35-39,共5页
Chinese Journal of Dermatology
关键词
表皮
儿童
青少年
角质层含水量
表皮通透屏障功能
透皮失水率
Epidermis
Child
Adolescent
Stratum corneum hydration
Epidermal permeability barrier
Transepidermal water loss
